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Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

机译:基于相位和幅度散斑可变性的无标签光学相干血管造影的血管对比度

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Recently proposed in vivo label-free optical coherence angiography techniques based on phase and amplitude speckle variability often require additional signal pre- and post processing operations to enhance vessel-contrast. Here, we discuss 1) contrast enhancement by optimizing the signal normalization/weighing before processing; 2) Kasai phase estimator based algorithm for phase compensation between processed A-scans to reduce masking role of motion artifacts; and 3) features of image projection through the imaging depth for en face plotting. We demonstrate the efficiency of these algorithms for in-vivo optical coherence angiography of hamsters' cheeks as a part of pre-clinical investigations, as well as preliminary microcirculation imaging of patients treated with radiation therapy. This technical framework complements our recent publications on M-Mode like OCT algorithm and its implementation.
机译:最近提出了基于相位和幅度散斑可变性的无Vivo标签的光学相干血管造影技术,通常需要额外的信号预处理和后处理操作来增强血管对比度。在这里,我们通过优化处理前的信号归一化/称重来讨论1)对比度增强; 2)基于Kasai相位估计的加工A-Scans的相位补偿算法,以减少运动伪影的掩蔽作用; 3)通过成像深度进行图像投影的特征,用于en面绘图。我们展示了这些途径对仓鼠脸颊的体内光学相干血管造影的效率作为临床前研究的一部分,以及用放射治疗治疗的患者的初步微循环成像。此技术框架补充了我们最近的M模式的出版物,如OCT算法及其实现。

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