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Plasma lipids profile and erythrocytes system in patients with coronary heart disease

机译:冠心病患者血浆脂质曲线和红细胞系统

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Erythrocytes system study can provide a framework for detailed exploration of blood cell-cell and cell-vessel wall interactions, one of the key patterns in blood and vascular pathophysiology. Our objective was to explore erythrocytes system in patients with stable angina pectoris II f.c. (Canadian classification). The participants (N = 56, age 40 - 55 years) without obesity, glucose tolerance violations, lipid lowering drugs treating, heart failure of It and more functional classes (NYHA), coronary episode at least 6 months before study were involved in the study. Blood samples were incubated with glucose solutions of increasing concentrations (from 2.5 % to 20 % with 2.5 % step) during 60 min (36°C). In prepared blood smears erythrocyte's sizes were studied. Plasma total cholesterol, triglyceride and glucose levels were also measured. Received data were approximated by polynomials of high degree, with after going first and second derivations. Erythrocytes system "behavior" was studied by means of phase pattern constructing. By lipids levels all the patient were divided into five groups: 1) patients with normal lipids levels, 2) patients with borderline total cholesterol level, 3) patients with isolated hypercholesterolemia, 4) patients with isolated hypertriglyceridemia and 5) patients with combined hyperlipidemia. Erythrocytes size lowering process was of set of "stages", which characteristics differ significantly (p > 0.05) in all five groups. Their rate and acceleration characteristics allow us to detect type of lipid profile in patients. Erythrocyte system disturbing by glucose concentration increase show to be most resistant in group of patients with isolated hypercholesterolemia.
机译:红细胞系统研究可以提供一种框架,用于详细探索血细胞和血管壁相互作用,血液和血管病理生理学的关键模式之一。我们的目标是探讨稳定的心绞痛患者IIC的红细胞系统。 (加拿大分类)。参与者(n = 56岁,年龄40 - 55岁)没有肥胖,葡萄糖耐量侵害,脂质降低药物治疗,IT和更多功能阶级(Nyha),冠心病至少在研究之前至少6个月,参与研究。在60分钟(36℃)期间,将血液样品与增加浓度的血糖溶液(在2.5%步长到2.5%)。在制备的血液中,研究了红细胞的尺寸。还测量血浆总胆固醇,甘油三酯和葡萄糖水平。收到的数据被高度的多项式近似,在第一和第二阶段之后。通过相位模式构建研究了红细胞系统“行为”。通过脂质水平,所有患者均分为五组:1)患者患有正常脂质水平的患者,2)患者患者患有邻近胆固醇水平的患者,3)患者分离出高胆固醇血症,4)患者患者分离过氧化物血症和5)患者组合高脂血症患者。红细胞尺寸降低过程是一组“阶段”,在所有五组中的特征在显着差异(p> 0.05)。它们的速率和加速度使我们能够检测患者的脂质谱的类型。通过葡萄糖浓度增加的红细胞系统扰动呈患者患者患者患者的分离出高胆固醇血症患者。

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