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Monitoring cellular remodeling of collageneous matrix using optical coherence tomographyMonitoring cellular remodeling of collageneous matrix using optical coherence tomography

机译：使用光相干断层扫描使用光学相干矩阵使用光学相干性矩阵的光学相干性囊性的蜂窝状改造的细胞重塑

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In this paper we develop the concept of a living optical phantom that uses engineered tissue as a phantom for calibration and optimization of biomedical optics instrumentation. With this method, the effects of biological processes on measured signals can be studied in a well controlled manner. To demonstrate this concept, the effects of cellular remodeling of a collagen matrix on the optical scattering properties were investigated using optical coherence tomography (OCT). Living optical phantoms of the vascular system were created by seeding smooth muscle cells in a collagen matrix. The optical scattering properties (scattering coefficient μ_s and effective anisotropy factor geff) were extracted from OCT images through mathematical processing. We found that the scattering coefficient of a remodeled matrix was generally higher than that of an unmodified matrix. The results indicate that OCT may provide meaningful information on how cellular remodeling of an extracellular collagen matrix changes its scattering properties. More broadly, we believe that making such optical measurements on living optical phantoms can help define the potential of biomedical optics technologies for studying biological systems.
机译：在本文中，我们开发了使用工程化组织作为校准和优化生物医学光学仪器的幻像的生物光学模型的概念。利用这种方法，可以以良好控制的方式研究生物过程对测量信号的影响。为了证明这种概念，使用光学相干断层扫描（OCT）研究了胶原蛋白基质对光散射特性的细胞重塑的影响。通过在胶原基质中播种平滑肌细胞来产生血管系统的活性光学幽灵。通过数学处理从OCT图像中提取光散射特性（散射系数μ_s和有效的各向异性因子Geff）。我们发现改造基质的散射系数通常高于未修饰基质的散射系数。结果表明，10月可以提供有关细胞外胶原基质的细胞重塑变化其散射性能的有意义信息。更广泛地，我们认为，在生活光学幻影上进行这种光学测量可以有助于定义用于研究生物系统的生物医学光学技术的潜力。

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