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首页> 外文会议>International Symposium on Energy and Protein Metabolism and Nutrition >Nutritional programming due to maternal high protein diet reduces offspring birth weight and body weight and is genotype dependent in mice
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Nutritional programming due to maternal high protein diet reduces offspring birth weight and body weight and is genotype dependent in mice

机译：由于母体高蛋白饮食导致的营养编程减少了后代出生体重和体重，并且是依赖于小鼠的基因型

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In many populations worldwide epidemiological evidence relates low birth weight to increased risk for syndrome X, coronary heart disease, and high blood pressure in adult age. On the basis of these observations it was suggested that low birth weight is causally related to foetal under- or malnutrition and subsequent foetal growth retardation or disproportionate growth which permanently affects adult health. An analysis of human data on dietary protein supplementation during pregnancy on the outcome of pregnancy came to the conclusion that high-protein or balanced protein supplementation alone is not beneficial and may be harmful to the infant (cited in Metges, 2005). We were the first to demonstrate in a rat model that maternal dietary high protein(HP) intake throughout pregnancy results in low birth weight, decreased energy expenditure and increased body fatness in the offspring (Daenzer et al., 2002). Recently, others have shown that maternal high protein diet during pregnancy and lactation programs blood pressure, food efficiency, and body weight (Thone-Reineke et al., 2006). We were now interested to know whether the observed effects of a maternal HP diet throughout pregnancy and/or lactation can be reproduced in mice and whether effects of maternal HP diet on offspring growth are genotype dependent.
机译：在许多群体中，全球流行病学证据将低出生体重与成人年龄的综合征x，冠心病和高血压的风险增加。在这些观察结果的基础上，建议低出生体重与胎儿或营养不良和随后的胎儿生长迟缓或不成比例的生长的因果关系，这些生长迟滞或者永久性地影响成人健康。对妊娠结局怀孕期间膳食蛋白质补充的人体数据的分析得出结论，即单独的高蛋白质或平衡蛋白质补充并不有益，可能对婴儿有害（在Metges，2005中引用）。我们是第一个在大鼠模型中展示的母体膳食高蛋白（HP）在整个妊娠中摄入的大鼠模型导致低出生体重，降低能量消耗和后代的体脂增加（Daenzer等，2002）。最近，其他人表明，孕产妇高蛋白质饮食在妊娠和哺乳期间血压，食品效率和体重（Thone-Reineke等，2006）。我们现在有兴趣了解母乳培养饮食的观察到妊娠和/或哺乳期的影响是否可以在小鼠中繁殖，以及母亲HP饮食对后代生长的影响是否依赖于基因型。

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