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首页> 外文会议>WSEAS International Conference on Fluid Mechanics >Application of fluid-structure interaction to investigate a malformed biological heart valve: a three dimensional study of the bicuspid aortic valve
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Application of fluid-structure interaction to investigate a malformed biological heart valve: a three dimensional study of the bicuspid aortic valve

机译：流体 - 结构相互作用研究畸形生物心脏瓣膜：三维研究的双裂主动脉瓣

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摘要

A Bicuspid Aortic Valve (BAV) is a congenital cardiovascular abnormality and is associated with aortic complications such as aortic stenosis (i.e. restricted opening of the valve). A three-dimensional fluid-structure interaction model has been developed to study the mechanical stress and fluid dynamics of a BAV. An idealised aorta model was generated and meshed. Material properties and boundary conditions were set accordingly to simulate blood and the natural aortic valve leaflets. Two main findings were that the BAV model was unable to open properly and that von Mises stress concentrated at the attachment to the aorta of the aortic valve cusps. Such changes are likely associated to the flow patterns predicted which included recirculation downstream from the valve itself and peak velocity between the valve cusps. These findings are important because they demonstrate that some of the clinical complications associated with a congenitally malformed aortic valve could caused by changes in the mechanical function of the biological heart valve.
机译：双囊主动脉瓣（BAV）是先天性心血管异常，与主动脉狭窄（例如受限制的瓣膜打开）有关。已经开发了一种三维流体结构相互作用模型来研究BAV的机械应力和流体动力学。生成并啮合了理想的主动脉模型。相应地设定了材料性质和边界条件以模拟血液和天然主动脉瓣传单。两种主要结果是，BAV模型无法正常打开，并且von误认为压力集中在主动脉瓣膜骨盆的主动脉的附件上。这种改变可能与预测的流动模式相关联，该流动模式包括从阀本身的下游的再循环和瓣膜尖瓣之间的峰值速度相关。这些发现很重要，因为它们证明了与先天性畸形的主动脉瓣相关的一些临床并发症可能是由生物心脏瓣膜的机械功能的变化引起的。

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