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首页> 外文会议>Recent researches in mechanical engineering >Application of fluid-structure interaction to investigate a malformed biological heart valve: a three dimensional study of the bicuspid aortic valve
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Application of fluid-structure interaction to investigate a malformed biological heart valve: a three dimensional study of the bicuspid aortic valve

机译：流体-结构相互作用在研究畸形生物心脏瓣膜中的应用：双尖瓣主动脉瓣的三维研究

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摘要

A Bicuspid Aortic Valve (BAV) is a congenital cardiovascular abnormality and is associated with aortic complications such as aortic stenosis (i.e. restricted opening of the valve). A three-dimensional fluid-structure interaction model has been developed to study the mechanical stress and fluid dynamics of a BAV. An idealised aorta model was generated and meshed. Material properties and boundary conditions were set accordingly to simulate blood and the natural aortic valve leaflets. Two main findings were that the BAV model was unable to open properly and that von Mises stress concentrated at the attachment to the aorta of the aortic valve cusps. Such changes are likely associated to the flow patterns predicted which included recirculation downstream from the valve itself and peak velocity between the valve cusps. These findings are important because they demonstrate that some of the clinical complications associated with a congenitally malformed aortic valve could caused by changes in the mechanical function of the biological heart valve.
机译：二尖瓣主动脉瓣膜（BAV）是先天性心血管异常，并伴有主动脉并发症，例如主动脉瓣狭窄（即瓣膜受限打开）。已经开发了三维流体-结构相互作用模型来研究BAV的机械应力和流体动力学。生成了理想的主动脉模型并进行了网格划分。相应地设置材料属性和边界条件以模拟血液和自然主动脉瓣小叶。两个主要发现是BAV模型无法正常打开，von Mises应力集中在主动脉瓣尖主动脉的附着处。此类变化可能与预测的流量模式相关，其中包括阀本身下游的再循环和阀尖之间的峰值速度。这些发现很重要，因为它们证明与先天畸形的主动脉瓣相关的一些临床并发症可能是由生物心脏瓣膜的机械功能改变引起的。

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