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首页> 外文会议>International Symposium on Nutritional Aspects of Osteoporosis >Vitamin D receptor Fokl polymorphism influences response to vitamin D supplementation in postmenopausal African-American women
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Vitamin D receptor Fokl polymorphism influences response to vitamin D supplementation in postmenopausal African-American women

机译：维生素D受体Fokl多态性影响绝经后非洲裔美国女性维生素D补充的反应

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In this double-blind study of postmenopausal black women (h=91), we hypothesized that vitamin D supplementation (1000 IU/day cholecalciferol) would prevent bone loss as compared to placebo, and furthermore that vitamin D receptor (VDR) polymorphisms might modify this response. Measurements of 25(OH)D, PTH, and bone turnover and bone mineral density (BMD) of the spine and hip were made at baseline, 3, 6, 12, and 24 months of the study. DNA was extracted from peripheral blood leukocytes and genotyping for the Fokl polymorphism was performed by PCR-RFLP. Serum 25(OH)D increased 11 ng/ml with vitamin D supplementation (P<0.001) and did not change in the placebo group, with no differences by genotype. There was greater PTH suppression with vitamin D as compared to placebo (both P<0.02) but only in the FF group. Furthermore, in FF subjects, the slope of BMD change in the hip in response to vitamin D supplementation was significantly less than the slope of bone loss in the placebo group (all P<0.001). However, there was no effect of vitamin D on BMD as compared to placebo in the Ff/ff group. Fokl polymorphism of the vitamin D receptor gene may alter the response of African-American women to vitamin D supplementation.
机译：在绝经后的黑人妇女（H = 91）的这项双盲研究中，我们推测，维生素d的补充（1000 IU /天胆钙化醇）将预防骨质流失与安慰剂相比，而且，维生素d受体（VDR）多态性可能修改这种反应。 25（OH）d，PTH，和骨转换和骨矿物质的脊柱和髋部的密度（BMD）的测量是在基线，3，6，12制成，并且该研究的24个月。 DNA从外周血白细胞和基因分型提取的FokI核酸多态性，通过PCR-RFLP进行。血清25（OH）d增加11毫微克/毫升维生素d补充（P <0.001）和在安慰剂组中没有变化，与由基因型没有差异。相比于安慰剂（两者P <0.02），但只有在FF组出现了较大的PTH抑制维生素d。此外，在FF受试者中，在髋BMD变化的响应维生素d补充斜率比骨损失的安慰剂组的斜率（所有P <0.001）显著以下。然而，相比于在FF / FF组安慰剂有维生素d对BMD没有影响。维生素d受体基因的多态性FokI结构可能改变非洲裔妇女的维生素d补充的响应。

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