Voltage-Dependent Calcium Channels in Renal Resistance Vessels

机译：肾电阻容器中的电压依赖性钙通道

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The renal resistance vessels control renal blood flow and the distribution of flow within the regions of the kidney. Excitation-contraction coupling in these vessels involves voltage-dependent calcium channels (Ca_v). Molecular studies show expression of both P-, L-, and T-type in myocytes from preglomerular vessels whereas no Ca_v was found in cortical efferent arterioles. In the muscular juxtamedullary efferent arterioles we found expression of T- and L-type Ca_v. Functional studies confirm involvement of Ca in the excitation-contraction mechanism of renal resistance vessels except cortical efferent arterioles. The demonstration of several different types of Ca_v and a differential expression in the renal resistance vasculature could be important for our understanding of pathological changes in renal hemodynamics and regulation of arterial blood pressure.

机译：肾蚀管控制肾血流量和肾脏区域内的流动分布。这些血管中的激发收缩耦合涉及电压依赖性钙通道（CA_V）。分子研究显示来自预流体血管的肌细胞中的p-，L-和T型的表达，而在皮质仿生动脉瘤中没有发现Ca_V。在肌肉曲率瘤屈曲的动脉中，我们发现表达T-和L型CA_V。功能性研究证实了Ca涉及除皮质迁移动脉外的肾性电阻容器的激发收缩机制中。肾脏抗性脉管系统中几种不同类型的CA_V和差异表达的证明对于我们对肾血流动力学的病理变化和动脉血压调节的理解是重要的。

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《World Congress for Microcirculation》|2007年||共10页
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P.B. Hansen; B.L. Jensen; U.G. Friis; D. Andreasen; T.R. Uhrenholt; O. Skott;
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机译：肾电阻容器中的电压依赖性钙通道
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7. Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle [O] . McCarron, John G., Olson, Marnie L., Currie, Susan, 2009

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8. Noradrenaline and Beta-Adrenoceptor Agonists Increase Activity of Voltage-Dependent Calcium Channels in Hippocampal Neurons [R] . Gray, R., Johnston, D. 1987

机译：去甲肾上腺素和β-肾上腺素受体激动剂增加海马神经元中电压依赖性钙通道的活性

Voltage-Dependent Calcium Channels in Renal Resistance Vessels

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