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HIV Infection in T-lymphocytes and Drug Induced CTL Response of a Time Delayed Model

机译:艾滋病毒感染在T淋巴细胞和药物诱导的CTL延迟模型的响应

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Drug therapy response of HIV-1 infected immune system is an important area of research by now. Today, a greater knowledge of drug induced CTL response allows us to better understand of cell mediated immune mechanism and humoral immune mechanism for viral infections. Moreover excessive stimulation of CTL in the immune system by different drugs leads to protective effects during natural infection with Human immunodeficiency virus of type-1. This paper concerns an application of drug therapy response to a mathematical model related to HIV-1 infection dynamics including a time delay in the removal of infected CD4+T cells or analogously in the process of viral replication. The model is analysed analytically as well as numerically. Our results show that delay affects considerably the attainability of the reduction of viral load in the HIV-1 infected system.
机译:HIV-1受感染免疫系统的药物治疗反应是现在的重要研究领域。今天,对药物诱导的CTL反应的更大了解使我们能够更好地理解细胞介导的免疫机制和体液免疫机制的病毒感染。此外,通过不同药物过量刺激免疫系统中的CTL导致人类免疫缺陷病毒的自然感染过程中的保护作用。本文涉及药物治疗响应对与HIV-1感染动态相关的数学模型的应用,包括在病毒复制过程中除去感染的CD4 + T细胞的时间延迟。分析地和数字分析模型。我们的研究结果表明,延迟大大影响了HIV-1感染系统中病毒载量减少的可达性。

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