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The influence of Licorice root flavonoids on antitumor efficiency of cyclophosphamide in vivo

机译：甘草根黄酮对体内环磷酰胺抗肿瘤效率的影响

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Contemporary researches of flavonoids demonstrate a wide range of their pharmacological activity.There is evidence that the basis mechanism of antiproliferative activity is the inhibition of phosphorylation ofintracellular signaling molecules (kinases, transcription factors). The aim of this study was to evaluate theantitumor effect of Licorice root flavonoids (LRF) against transplantable murine tumor model – P388lymphocytic leukemia, and to compare the antitumor effect of the combination cyclophosphamide (CP) + LRFagainst that model. Evaluation was carried out in a parallel comparison of the: control group, group that wasadministered intraperitoneally CP 24 h after inoculation of tumor material (1st day of tumor growth), groupreceiving a combination of drugs CP + LRF. The following parameters were calculated: average life expectancy(ALE), the increase of life expectancy (ELE) and the therapeutic win (TW). These findings demonstrated thatLRF (10 mg/kg) has no significant antitumor effect, however LRF potentiates the antitumor effect of CP (100mg/kg) against transplantable murine tumor model. Thereby, the LRF may be perspective agents for thedevelopment on their basis drugs for combined anticancer therapy.
机译：黄酮类化合物的当代研究表现出宽范围的它们的药理学activity.There的证据表明，抗增殖活性的基础机制是磷酸化ofintracellular信号传导分子（激酶，转录因子）的抑制。本研究的目的是评价甘草类黄酮（LRF）针对可移植鼠肿瘤模型的效果theantitumor - P388lymphocytic白血病和比较组合环磷酰胺（CP）+ LRFagainst该模型的抗肿瘤效果。评价是在一个平行比较来进行：对照组，肿瘤材料（肿瘤生长的第一天）接种后wasadministered腹腔CP 24 h组，groupreceiving药物CP + LRF的组合。计算以下参数：平均寿命（ALE），寿命（ELE）和治疗赢（TW）的增加。这些发现证明thatLRF（10毫克/千克）无显著的抗肿瘤效果，但是LRF potentiates CP（100毫克/千克）对可移植小鼠肿瘤模型的抗肿瘤效果。由此，LRF可以是立体剂在其基础药物用于联合抗癌疗法thedevelopment。

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