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首页> 外文会议>International Conference on Environmental, Industrial and Applied Microbiology >Effect of cell surface components on ASABF-α susceptibility in Staphylococcus aureus: a resistance mechanism involving cell wall alteration
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Effect of cell surface components on ASABF-α susceptibility in Staphylococcus aureus: a resistance mechanism involving cell wall alteration

机译：细胞表面成分对金黄色葡萄球菌沥青α易感性的影响：涉及细胞壁改变的电阻机理

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ASABF-α (Ascaris suum antibacterial factor) susceptibility is variable among S. aureus strains, but its mechanism is still elusive. In our analysis examining the relevance of the phospholipid composition to the ASABF-α resistance, lower amounts of cardiolipin (CL) were detected from the ASABF-α resistant strains probably due to their thick cell walls that interfered with the extraction of CL. Indeed, when the cell wall was destructed by lysostaphin, the extracted CL from each strain was indistinguishable irrespective of the ASABF-α resistance. Furthermore, the deletion of two CL synthase genes did not affect the ASABF-α susceptibility. Taken together, the physical characteristics of the cell surface, rather than the CL content, was supported as an important factor interfering with the ASABF-α activity.
机译：ASABF-α（蛔虫抗菌因子）易感性在S.UUREUS菌株中是可变的，但其机制仍然是难以捉摸的。在我们的分析中，检查磷脂组合物与沥青-α抗性的相关性，可能由于其厚的细胞壁而从厚度的细胞壁被干扰加入Cl的厚细胞壁来检测较低量的肺炎素蛋白（CL）。实际上，当通过溶溶素素破坏细胞壁时，来自每个菌株的提取的CL与无论沥青-α抗性无关。此外，两种Cl合酶基因的缺失不影响ASABF-α易感性。连胜，将细胞表面的物理特性（而不是Cl含量）作为干扰ASABF-α活性的重要因素。

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