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首页> 外文会议>International Conference on Environmental, Industrial and Applied Microbiology >Metabolic reconstruction of Synechococcus elongatus towards a minimal photoautotrophic cell
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Metabolic reconstruction of Synechococcus elongatus towards a minimal photoautotrophic cell

机译：SyneChocccus Elongatus朝向最小光学营养细胞的代谢重建

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The cyanobacterium Synechococcus elongatus strain PCC 7942 is a unicellular, obligate photoautotroph that represents a model organism for studies of photosynthesis, circadian rhythm, cell division and carbon-concentrating mechanisms. The recently completed sequencing of its genome gives the opportunity to attempt a reconstruction of a genome-scale computational model of its metabolic processes. Towards this goal, we are currently refining the annotation of this microorganism relaying mostly on primary scientific literature and aided by information from various biological databases (KEGG, Brenda, TCDB). Until now, we were able to newly identify or to confirm 351 connections linking a particular gene to its molecular function, which constitute approximately 13.5% of protein coding genes of this cyanobacterium. Once the refinement is finished, we will perform a constraint-based analysis to assess metabolic capabilities, including growth yield and gene essentiality, and to predict a minimal photoautotrophic cell.
机译：蓝藻细长聚球藻PCC 7942株是单细胞，专性光能自养表示用于光合作用，昼夜节律，细胞分裂和碳浓缩机制的研究的模型生物。它的基因组最近完成测序使有机会尝试它的代谢过程的基因组规模计算模型的重建。为了实现这一目标，我们目前正在完善这一微生物大多中继上小学科学文献的注释和由各种生物数据库（KEGG，布伦达，TCDB）信息帮助。到现在为止，我们能够识别新的或确认351个连接的连接特定基因的分子功能，构成的这个蓝藻的蛋白质编码基因的大约13.5％。一旦细化完毕后，我们将进行基于约束的分析来评估代谢功能，包括生长和产量的基因重要性，并预测最小的光合自养细胞。

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