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首页> 外文会议>International forum on post-genome technologies >HCV CORE FRAME SHIFT PROTEIN, F PROTEIN, SHARES THE REPRESSION OF P21 PROMOTER ACTIVITY WITH CORE PROTEIN
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HCV CORE FRAME SHIFT PROTEIN, F PROTEIN, SHARES THE REPRESSION OF P21 PROMOTER ACTIVITY WITH CORE PROTEIN

机译：HCV核心框架移位蛋白，F蛋白，与核心蛋白征收P21启动子活性的抑制

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Hepatitis C virus (HCV) core protein was proven previously to repress transcription of the universal cyclin-dependent kinase (CDK) inhibitor p21 gene, as demonstrated by in vitro transient expression assays using murine fibroblasts (NIH3T3), human hepatocellular carcinoma (HepG2) and human cervical carcinoma (HeLa) cells. Researchers have found a new HCV protein, termed as F protein, which is encoded from an alternative +1 reading frame overlapping the core genomic region. In this study, we investigated whether or not F protein repressed transcription of the universal cyclin-dependent kinase inhibitor p21 gene as core protein did. From the transient reporter assays of p21 promoter, we found that F protein, similar but not the same as core protein, repressed transcriptional modulation of p21 gene. So we concluded that F protein can regulate p21 promoter, which were previously attributable to core protein expression.
机译：先前证明丙型肝炎病毒（HCV）核心蛋白以抑制通用细胞周期蛋白依赖性激酶（CDK）抑制剂P21基因的转录，如使用鼠成纤维细胞（NIH3T3），人肝细胞癌（Hepg2）和人宫颈癌（Hela）细胞。研究人员发现了一种新的HCV蛋白，称为F蛋白质，其由重叠核心基因组区域重叠的替代+1读数框架。在这项研究中，我们研究了通用细胞周期蛋白依赖性激酶抑制剂P21基因的F蛋白抑制转录是否为核心蛋白质。从P21启动子的瞬时报告分析中，我们发现F蛋白，类似但与核心蛋白相似，抑制P21基因的转录调节。因此，我们得出结论，F蛋白可以调节P21启动子，其先前可归因于核心蛋白表达。

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