HCV CORE FRAME SHIFT PROTEIN, F PROTEIN, SHARES THE REPRESSION OF P21 PROMOTER ACTIVITY WITH CORE PROTEIN

机译：HCV核心框架转移蛋白F蛋白与核心蛋白共同抑制P21启动子活性

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Hepatitis C virus (HCV) core protein was proven previously to repress transcription of the universal cyclin-dependent kinase (CDK) inhibitor p21 gene, as demonstrated by in vitro transient expression assays using murine fibroblasts (NIH3T3), human hepatocellular carcinoma (HepG2) and human cervical carcinoma (HeLa) cells. Researchers have found a new HCV protein, termed as F protein, which is encoded from an alternative +1 reading frame overlapping the core genomic region. In this study, we investigated whether or not F protein repressed transcription of the universal cyclin-dependent kinase inhibitor p21 gene as core protein did. From the transient reporter assays of p21 promoter, we found that F protein, similar but not the same as core protein, repressed transcriptional modulation of p21 gene. So we concluded that F protein can regulate p21 promoter, which were previously attributable to core protein expression.

机译：先前已证明丙型肝炎病毒（HCV）核心蛋白可抑制通用细胞周期蛋白依赖性激酶（CDK）抑制剂p21基因的转录，如使用鼠类成纤维细胞（NIH3T3），人肝细胞癌（HepG2）和人宫颈癌（HeLa）细胞。研究人员发现了一种新的HCV蛋白，称为F蛋白，该蛋白由与核心基因组区域重叠的+1阅读框编码。在这项研究中，我们调查了F蛋白是否像核心蛋白一样抑制普遍的细胞周期蛋白依赖性激酶抑制剂p21基因的转录。从p21启动子的瞬时报告基因检测中，我们发现与核心蛋白相似但不相同的F蛋白抑制了p21基因的转录调控。因此，我们得出的结论是F蛋白可以调节p21启动子，而p21启动子以前是由于核心蛋白的表达引起的。

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来源
《The 6'th International Forum on Post-genome Technologies(6'IFPT)（第六届国际后基因组生命科学技术学术论坛）》|2009年|332-335|共4页
会议地点 Beijing(CN);Beijing(CN)
作者
Kong Jing; Deng Xiaozhao; Zhang Yun; Wang Zhongchan; Chu Chunli; Yu Juan; Li Chunlei;
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作者单位

Medical Institute of Nanjing Army, Nanjing 210002, China Faculty of Life Scence Chemical Engineering, Huaiyin Institute of Technology, Hua'an 223300, China;

Medical Institute of Nanjing Army, Nanjing 210002, China;

Medical Institute of Nanjing Army, Nanjing 210002, China;

Medical Institute of Nanjing Army, Nanjing 210002, China;

Medical Institute of Nanjing Army, Nanjing 210002, China;

Medical Institute of Nanjing Army, Nanjing 210002, China;

Medical Institute of Nanjing Army, Nanjing 210002, China;

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正文语种 eng
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关键词
Hepatitis C virus (HCV); F protein; core protein; p21 promoter;

机译：丙型肝炎病毒（HCV）； F蛋白；核心蛋白p21启动子;

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专利

1. runt Homology Domain Transcription Factors (Runx, Cbfa, and AML) Mediate Repression of the Bone Sialoprotein Promoter: Evidence for Promoter Context-Dependent Activity of Cbfa Proteins [J] . Amjad Javed, George L. Barnes, B. O. Jasanya, Molecular and Cellular Biology . 2001,第8期

机译：矮小同源域转录因子（Runx，Cbfa和AML）介导骨唾液蛋白启动子的阻遏：Cbfa蛋白启动子上下文相关活性的证据
2. The repressive activity of hepatitis C virus core protein on the transcription of p21(waf1) is regulated by protein kinase A-mediated phosphorylation. [J] . Jung EY, Lee MN, Yang HY, Virus Research: An International Journal of Molecular and Cellular Virology . 2001,第1a2期

机译：丙型肝炎病毒核心蛋白对p21（waf1）转录的抑制活性受蛋白激酶A介导的磷酸化的调节。
3. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. [J] . Iacobelli M, Wachsman W, McGuire KL The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第2期

机译：新型碱性亮氨酸拉链p21SNFT蛋白抑制IL-2启动子活性。
4. HCV CORE FRAME SHIFT PROTEIN, F PROTEIN, SHARES THE REPRESSION OF P21 PROMOTER ACTIVITY WITH CORE PROTEIN [C] . International forum on post-genome technologies . 2009

机译：HCV核心框架移位蛋白，F蛋白，与核心蛋白征收P21启动子活性的抑制
5. Elucidating the Role of Ribosomal Frameshifting during HCV Core Protein Translation, and the Putative Effects of Alternative Reading Frame Proteins (ARFPs/F-Proteins). [D] . Nassiri, Yousef. 2015

机译：阐明了核糖体移码在HCV核心蛋白翻译过程中的作用，以及其他阅读框蛋白（ARFP / F蛋白）的假定作用。
6. Expression and Purification of HCV Core and Core-E1E2 Proteins in Different Bacterial Strains [O] . Seyyedeh Masumeh Mirnurollahi, Azam Bolhassani, Shiva Irani, 2015

机译：HCV核心蛋白和核心E1E2蛋白在不同细菌菌株中的表达和纯化
7. Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein [O] . Han Hae Jin, Jung Eun Young, Lee Woo Jung, 2002

机译：乙型肝炎病毒X蛋白和丙型肝炎病毒核心蛋白协同抑制细胞周期蛋白依赖性激酶抑制剂p21基因表达

HCV CORE FRAME SHIFT PROTEIN, F PROTEIN, SHARES THE REPRESSION OF P21 PROMOTER ACTIVITY WITH CORE PROTEIN

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