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首页> 外文会议>International Conference on Artificial Intelligence and Pattern Recognition >A Computational Study on Effects of Pairing BAPs and EPSPs in Medium Spiny Neurons of Nucleus Accumbens
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A Computational Study on Effects of Pairing BAPs and EPSPs in Medium Spiny Neurons of Nucleus Accumbens

机译：对核心腺中刺骨神经元的配对容纳和epsps效应的计算研究

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Nucleus accumbens (NAc) or ventral striatum is a major site of action for many drugs of abuse and is implicated in mood disorders and schizophrenia. It is a critical structure of brain reward circuit acting as a limbic/motor interface to decide whether a goal is worth pursuing. Responses of medium spiny (MS) neurons, which constitute the principal cells in striatum, changes during reward related behavior. Because of the tiny structure of these neurons, experimental studies on biophysical properties of these neurons are very sparse (very few in dorsal striatum) and such studies have not yet been conducted in MS neurons of NAc. Here we use a computational model to investigate whether the pairing of excitatory postsynaptic potentials (EPSPs) and backpropagating action potentials (BAPs) results in a non linear calcium influx that is NMDA dependent. It is found that, similar to other central neurons, pairing EPSPs and BAPs results in enhanced calcium entry which is NMDA dependent during normal as well as bursting modes of firing in NAc MS neurons.
机译：Nucleumens（NAC）或腹侧纹状体是许多滥用药物的主要行动部位，涉及情绪障碍和精神分裂症。它是脑奖励电路的临界结构，作为肢体/电机界面，以决定目标是否值得追求。中等刺（MS）神经元的反应，构成纹状体中的主要细胞，在奖励相关行为期间发生变化。由于这些神经元的微小结构，这些神经元的生物物理性质的实验研究非常稀疏（背体中很少），并且在NAC的MS神经元中尚未进行这些研究。在这里，我们使用计算模型来研究兴奋性突触潜力（EPSP）和背部衰减动作电位（BAPS）的配对是否导致非线性钙流入，其依赖于NMDA。发现类似于其他中枢神经元，配对EPSP和阀圈导致增强的钙入口，其在正常期间依赖于NMDA以及在NAC MS神经元中烧制的爆发模式。

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