Fragmentation Pattern of Glycated Peptides Derived from D-glucose by Tandem Mass Spectrometry

机译：通过串联质谱法衍生自D-葡萄糖的糖化肽的碎片模式

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Evidence shows that non-enzymatic glycation plays an important role in the development of diabetes, diabetes-related complications and neurodegenerative diseases. Mass spectrometric methods have been used for non-enzymatic glycation of proteins. At present, CID remains the major fragmentation method for peptide sequencing. In this study, we utilized synthesized peptide models to study fragmentation spectra of glycated peptides, which can be easily studied using ESI-MS. MS/MS fragmentation whose characteristics of glycated peptides will help for large-scale glycated proteomics analyses of complex plasma and tissue samples.

机译：证据表明，非酶促甘露解在糖尿病，糖尿病相关的并发症和神经变性疾病的发展中起重要作用。质谱法已用于蛋白质的非酶促糖糖。目前，CID仍然是肽测序的主要碎片方法。在该研究中，我们利用合成的肽模型来研究糖化肽的碎片光谱，可以使用ESI-MS容易地研究。 MS / MS碎片的糖化肽的特性将有助于大规模糖化蛋白质组学分析复合血浆和组织样品。

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《ICME International Conference on Complex Medical Engineering》|2013年||共4页
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作者
Rui Su; Yahui Liu; Yun Wang; Yongqian zhang; Qing Hong; Yulin Deng;
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中图分类 R319-53;
关键词
Non-enzymatic glycation; Fragmentation; CID; neutral loss;

机译：非酶促糖化;碎片;CID;中性损失;

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1. Conversion of arginine to ornithine for improving the fragmentation pattern of peptides labeled with the N-terminal tris(2,4,6-trimethoxyphenyl)-phosphonium group in tandem mass spectrometry [J] . Hiroki Kuyama, Chihiro Nakajima, Takashi Nakazawa Analytical methods . 2010,第11期

机译：精氨酸向鸟氨酸的转化以改善串联质谱法中被N端三（2,4,6-三甲氧基苯基）-基团标记的肽的片段化模式
2. Conversion of arginine to ornithine for improving the fragmentation pattern of peptides labeled with the N-terminal tris(2,4,6-trimethoxyphenyl)phosphonium group in tandem mass spectrometry [J] . Chihiro Nakajima, Takashi Nakazawa, Osamu Nishimura Analytical methods . 2010,第11期

机译：精氨酸向鸟氨酸的转化以改善串联质谱法中被N端三（2,4,6-三甲氧基苯基）phosph基团标记的肽的片段化模式
3. 23rd Sanibel Conference on Mass Spectrometry: From fragmentation mechanisms to sequencing: tandem mass spectrometry based peptide and protein identification [J] . Paizs B., Mann M. Journal of the American Society for Mass Spectrometry . 2012,第4期

机译：第23届Sanibel质谱会议：从断裂机理到测序：基于串联质谱的肽和蛋白质鉴定
4. Fragmentation pattern of glycated peptides derived from D-glucose by tandem mass spectrometry [C] . Su Rui, Liu Yahui, Wang Yun, 2013 ICME International Conference on Complex Medical Engineering . 2013

机译：串联质谱分析D-葡萄糖衍生的糖基化肽的片段化模式
5. Using peak intensity and fragmentation patterns in peptide sequence identification (SQID): A Bayesian learning algorithm for tandem mass spectra. [D] . Ji, Li. 2006

机译：在肽序列识别（SQID）中使用峰强度和片段化模式：串联质谱的贝叶斯学习算法。
6. High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants [O] . Baradwaj Gopal Ravi, Mary Grace E. Guardian, Rebecca Dickman, 2020

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7. Analysis of Non-Enzymatically Glycated Peptides: Neutral-Loss Triggered MS3 Versus Multi-Stage Activation Tandem Mass Spectrometry [O] . Zhang, Qibin, Petyuk, Vladislav A., Schepmoes, Athena A., 2008

机译：非酶促糖化肽的分析：中性丢失触发ms3与多级激活串联质谱

Fragmentation Pattern of Glycated Peptides Derived from D-glucose by Tandem Mass Spectrometry

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