• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Symposium on Natural Genetic Engineering and Natural Genome Editing >Cellular Genes Derived from Gypsy/Ty3 Retrotransposons in Mammalian Genomes
【24h】

Cellular Genes Derived from Gypsy/Ty3 Retrotransposons in Mammalian Genomes

机译：在哺乳动物基因组中衍生自Gypsy / Ty3转回转储的细胞基因

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Gypsy/Ty3 retrotransposons, a group of long terminal repeat retrotransposons relatedto vertebrate retroviruses, are found in the genome of many fungi, plants, and animals.Although multiple families of such retroelements are present in fish, active Gypsy/Ty3retrotransposons have all been eliminated from the lineage leading to mammals at least180 million years ago. However, over 50 cellular genes related to Gypsy/Ty3 retrotrans-posons have been identified in mammalian genomes, indicating recurrent "moleculardomestication" of these elements by their host during evolution. Most retrotransposon-derived proteins are conserved in divergent mammalian species and show sequencesimilarity to Gag proteins, major structural proteins for retroelement particle forma-tion. Among the proposed and demonstrated biological functions forgag-derived genes,placenta formation in the mouse requires two gag-derived genes from the same fam-ily. Some forms of epigenetic regulation of gag-related genes might derive from hostgenome defense mechanisms that repelled retrotransposon ancestors. Together, suchobservations support a major role for transposable elements as a source of new codingsequences allowing important genetic innovations during evolution.
机译：吉普赛/ TY3反转录转座子，一组长末端重复反转录转座子的脊椎动物相关结果关于逆转录病毒，在许多真菌，植物的基因组中发现，这种反转录因子的animals.Although多个家庭中存在的鱼，活性吉普赛/ Ty3retrotransposons已全部消除从沿袭导致哺乳动物在least180万年前。然而，与吉普赛/ TY3 retrotrans-posons 50细胞基因已在哺乳动物基因组鉴定，这表明经常性这些元素通过它们的宿主进化过程中的“moleculardomestication”。大多数反转录转座子来源的蛋白质是保守的不同哺乳动物物种，并显示sequencesimilarity到加格蛋白，r​​etroelement颗粒备考，重刑主要结构蛋白。间forgag衍生基因提出并实现了生物功能，在小鼠胎盘形成需要从相同的FAM-ILY 2 GAG衍生的基因。插科打诨的相关基因的表观遗传调控的一些形式可能不同于击退反转录转座子的祖先hostgenome防御机制派生。总之，suchobservations支持转元素的新codingsequences允许在进化过程中的重要基因的创新源的重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号