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首页> 外文会议>SPIE Conference on Colloidal Quantum Dots for Biomedical Applications >Whispering-Gallery Mode Based Biosensing Using Quantum Dot-Embedded Microspheres
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Whispering-Gallery Mode Based Biosensing Using Quantum Dot-Embedded Microspheres

机译：基于耳语的画廊模式使用量子点嵌入式微球的生物传感

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摘要

Highly sensitive, miniature biosensors are desired for the development of new techniques for biological and environmental analyte sensing. One potential approach uses the detection of optical resonances, known as Whispering Gallery Modes (WGMs), from quantum dot embedded polystyrene microspheres. These modes arise from the total internal reflection of the quantum dot emission light within the high index polystyrene microsphere, to produce narrow spectral peaks, which are sensitive to refractive changes in the immediate vicinity of the microsphere surface. The high refractometric sensitivity of the WGMs in these microspheres offers potential for remote detection of molecules adsorbed onto or bound to the microsphere surface without the need for direct coupling of the light via an optical fiber. The sensitivity of these modes has been shown to exceed the theoretical sensitivity of a homogeneous microsphere, using a Mie theory model. This enhancement is believed to be due to the embedded layer of quantum dots at the surface of the microspheres. A model was developed to demonstrate that the embedded QDs could be modeled as a high index outer layer to explain the observed WGM spectra and explore the sensitivity of the modes. In this work, we extend this idea to multiple layers to model the effects of protein adsorption or binding to the surface. The theoretical results are shown to provide a close fit to our previous experimental results.
机译：期望高敏感的微型生物传感器，用于开发生物和环境分析物感测的新技术。一种潜在方法使用量子点嵌入聚苯乙烯微球的光学共振检测，称为低语展示廊道模式（WGM）。这些模式从高指数聚苯乙烯微球内的量子点发射光的总内反射产生，产生窄光谱峰，这对微球表面的直接附近的折射变化敏感。这些微球中WGM的高折射率灵敏度提供了远程检测吸附到微球表面或与微球表面结合的分子的电位，而无需通过光纤直接耦合光。已经显示出这些模式的敏感性超过使用MIE理论模型的均匀微球的理论敏感性。这种增强被认为是由于微球表面的嵌入式量子点层。开发了一种模型，以证明嵌入的QD可以被建模为高索引外层以解释观察到的WGM光谱并探索模式的灵敏度。在这项工作中，我们将此想法扩展到多层以模拟蛋白质吸附或结合表面的影响。显示理论结果，提供了对我们以前的实验结果密切合适。

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