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首页> 外文期刊>Annals of Biomedical Engineering: The Journal of the Biomedical Engineering Society >Whispering gallery mode biosensors consisting of quantum dot-embedded microspheres.
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Whispering gallery mode biosensors consisting of quantum dot-embedded microspheres.

机译：由嵌入量子点的微球组成的回音壁模式生物传感器。

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摘要

New methods of biological analyte sensing are needed for development of miniature biosensors that are highly sensitive and require minimal sample preparation. One technique employs optical resonances, known as whispering gallery modes (WGMs), in spherical or cylindrical microstructures. The spectral positions of these resonant modes are very sensitive to the local refractive index and spectral shifts may be used to sense changes in the index. To excite these WGMs and enable remote excitation, quantum dots are embedded in polystyrene microspheres to serve as local light sources. Using a simple continuous wave excitation optical system, these sensors are demonstrated by monitoring the wavelength shift of multiple resonant modes as bulk index of refraction is changed in ethanol-water mixtures. The potential for targeted biosensing is explored through addition of a protein that adsorbs to the microsphere surface, thrombin, and one that does not, bovine serum albumin (BSA). The thrombin produced a spectral shift that was much larger than that due to the bulk index change. The BSA produced a significantly smaller shift that was slightly larger than the expected shift due to bulk index change. Most likely due to the thin, high index layer of quantum dots, microsensor response in all cases demonstrated increased sensitivity over theoretical predictions.
机译：开发高度灵敏且需要最少样品制备的微型生物传感器需要生物分析物传感的新方法。一种技术采用球形或圆柱形微结构中的光学共振，称为回音壁模式（WGM）。这些共振模式的光谱位置对局部折射率非常敏感，光谱位移可用于检测折射率的变化。为了激发这些WGM并实现远程激发，将量子点嵌入聚苯乙烯微球中以用作局部光源。使用简单的连续波激发光学系统，通过监测乙醇-水混合物中的整体折射率变化时多个共振模的波长偏移，可以演示这些传感器。通过添加一种吸附到微球表面的蛋白质，凝血酶和一种不吸附在牛血清白蛋白（BSA）上的蛋白质，探索了靶向生物传感的潜力。凝血酶产生的光谱偏移比由于整体指数变化而产生的光谱偏移大得多。由于总体指数的变化，BSA产生的变动明显较小，略大于预期的变动。最有可能是由于量子点的薄而高折射率层，在所有情况下，微传感器响应都显示出比理论预测更高的灵敏度。

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