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首页> 外文会议>International Conference on Systems in Medicine and Biology >Expression of #x03B1;v#x03B2;3 integrin, leukemia inhibitory factor and pinopodes as markers of endometrial receptivity in idiopathic recurrent spontaneous miscarriage
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Expression of #x03B1;v#x03B2;3 integrin, leukemia inhibitory factor and pinopodes as markers of endometrial receptivity in idiopathic recurrent spontaneous miscarriage

机译：α v β 3 整合蛋白，白血病抑制因子和探头作为特发性复发性自发性流产的子宫内膜受接受的标志物

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Objective: An understanding of the endometrial receptivity during embryo implantation is essential to avoid recurrent spontaneous miscarriage (RSM). Expression of endometrial receptivity markers including αvβ3 integrin and Leukemia Inhibitory Factor (LIF) and pinopodes in women with RSM is explored. Design: Endometrial tissue samples were collected from 16 women with idiopathic RSM (age<;60;35 years) during the mid-secretory phase (D21) of the menstrual cycle from the Institute of Reproductive Medicine, Salt lake, Kolkata, West Bengal, India. 12 normal women having partners with male factor infertility were taken as controls. Only those women who did not receive any kind of medication and had no known causes of miscarriage or other gynecological disorders were included in this study. Materials and Methods: The collected tissue was divided into three parts: one part was used for stromal and epithelial cells isolation for flow cytometric analysis of the biochemical markers, the other part was fixed for immunohistological staining. The third part was also fixed and examined for pinopodes using SEM. Data were compared using independent two sample `t' test and chi-square test, as applicable. Statistical significance was defined as p ≤0.05. Results: Expression of αvβ3 integrin, LIF and pinopodes were observed to be significantly less, both in stromal and epithelial cells of the endometrium in women with RSM when compared with controls. Conclusions: Poor expression of the molecular mediators, αvβ3 integrin and LIF in women with RSM correlates well with poor endometrial receptivity. In view of the fact that pinopodes are essential for successful embryo implantation, it is suggested that morphologically abnormal pinopodes in RSM is possibly one of the main causes adversely affecting implantation of the embryo.
机译：目的：对胚胎植入过程中的子宫内膜受接受是必不可少的，以避免复发自发流产（RSM）。探讨了包括α v β 3 3 整联蛋白和白血病抑制因子（LIF）和船舶探测器的子宫内膜接受标志物的表达。设计：在生殖医学研究所，盐湖，加尔各答，西孟加拉邦的月经周期中分泌阶段（D21）中，从16名妇女收集子宫内膜组织样品（年龄<; 60; 60; 35岁）。印度。 12名与男性因子不孕症的正常妇女被视为对照。在本研究中只有那些没有接受任何药物的女性，没有任何药物疾病的妇女或没有已知的流产或其他妇科疾病的原因。材料和方法：将收集的组织分为三个部分：一部分用于基质和上皮细胞的分离，用于生物化学标记的流式细胞术分析，另一部分用于免疫组织染色。还使用SEM固定第三部分并检查探索码。使用独立的两个样品`T'测试和Chi-Square测试进行比较数据，如适用。统计显着性定义为p≤0.05。结果β<子> 3 整，LIF和胞饮突观察为显著少，无论是在基质和在妇女与RSM子宫内膜上皮细胞的情况相比α<子> V表达的控制。结论：分子介质的表达不良，α v β 3 整合蛋白和LIF在患有较差的子宫内膜接受性。鉴于探井码对于成功胚胎植入是必不可少的事实，建议RSM中的形态学异常的探头可能是主要导致胚胎植入的主要原因之一。

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