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首页> 外文会议>International Symposium on Therapeutic Ultrasound (2002-) >Color Doppler Sonographic Evaluation of Peak Systolic Velocity and Pulsatility Index in Artery after Pulsed HIFU Exposure
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Color Doppler Sonographic Evaluation of Peak Systolic Velocity and Pulsatility Index in Artery after Pulsed HIFU Exposure

机译：脉冲Hifu暴露后动脉峰值收缩速度和脉动性指数的彩色多普勒超声评估

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The objective of current study was to investigate the functional changes in arteries induced by pulsed-HIFU with or without microbubbles. Sonication was applied at an ultrasound frequency of 1 MHz with a burst length of 50ms and a repetition frequency of 1 Hz. The duration of the whole sonication was 6s. The abdominal aortas of Sprague-Dawley rats were surgically exposed and sonicated with pulsed HIFU; the pulsed HIFU beam was aimed using color images of the blood flow. There was no obvious normalized peak systolic velocity (PSV) change at various acoustic powers of pulsed-HIFU exposure in the absence of ultrasound contrast agent (UCA). However, the normalized PSV change induced by pulsed-HIFU decreased with the injected dose of UCA at acoustic powers. At this time, the normalized pulsatility index (PI) change in the vessel subjected to pulsed-HIFU increased in proportion to UCA dose. Additional research is needed to investigate the detailed mechanical effects of pulsed-HIFU exposure on blood flow and the structure of vessel walls.
机译：目前研究的目的是研究脉冲 - HIFU与微泡的脉冲 - HIFU诱导的动脉的功能变化。超声波处理以1 MHz的超声频率施加，突发长度为50ms，重复频率为1 Hz。整个超声处理的持续时间为6s。 Sprague-Dawley大鼠的腹部主动脉通过脉冲Hifu手术暴露和超声处理;脉冲HIFU光束旨在使用血流的彩色图像。有在脉冲-HIFU暴露在无超声造影剂（UCA）的各种声功率没有明显的归一化的收缩期峰值流速（PSV）的变化。然而，脉冲-HIFU诱导的归一化PSV变化随着声功率的注射剂量的UCA降低。此时，经受脉冲 - HIFU的血管中的归一化脉冲指数（PI）变化与UCA剂量成比例增加。需要额外的研究来研究脉冲 - HIFU暴露对血流和血管壁结构的详细机械效应。

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