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首页> 外文会议>SPIE Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Micro-CT characterization of human trabecular bone in osteogenesisimperfecta
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Micro-CT characterization of human trabecular bone in osteogenesisimperfecta

机译：骨质源性血拷贝中人小梁骨的微型CT表征

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Osteogenesis imperfecta (OI) is a genetic syndrome affecting collagen synthesis and assembly. Its symptoms vary widely but commonly include bone fragility, reduced stature, and bone deformity. Because of the small size and paucity of human specimens, there is a lack of biomechanical data for OI bone. Most literature has focused on histomorphometric analyses, which rely on assumptions to extrapolate 3-D properties. In this study, a micro-computed tomography ()JET) system was used to directly measure structural and mineral properties in pediatric DI bone collected during routine surgical procedures. Surface renderings suggested a poorly organized, plate-like orientation. Patients with a history of bone-augmenting drugs exhibited increased bone volume fraction (BV/TV), trabecular number (Tb.N), and connectivity density (Eu.Conn.D). The latter two parameters appeared to be related to OI severity. Structural results were consistently higher than those reported in a previous histomorphometric study, but these differences can be attributed to factors such as specimen collection site, drug therapy, and assumptions associated with histomorphometry. Mineral testing revealed strong correlations with several structural parameters, highlighting the importance of a dual approach in trabecular bone testing. This study reports some of the first quantitative i.iCT data of human CM bone, and it suggests compelling possibilities for the future of OI bone assessment.
机译：osteogenesis渗透细胞（OI）是一种影响胶原合成和组装的遗传综合症。其症状广泛变化但通常包括骨脆性，降低的身材和骨骼畸形。由于人类标本的尺寸小，缺乏缺乏oi骨的生物力学数据。大多数文献都集中于组织素质分析，依赖于外推3-D特性的假设。在该研究中，微计算机断层摄影（）喷射）系统用于直接测量在常规外科手术过程中收集的小儿DI骨中的结构和矿物质。表面渲染表明有一个糟糕的组织，板式方向。患者的骨增强药物史显示出增加的骨体积分数（BV / TV），小梁骨数量（Tb.N），和连接密度（Eu.Conn.D）。后两种参数似乎与oi严重性有关。结构结果始终高于先前的组织形态学研究中报告的结果，但这些差异可归因于标本收集部位，药物治疗和与组织形态学相关的假设等因素。矿物检测揭示了与若干结构参数的强烈相关性，突出了双重方法在小梁骨测试中的重要性。本研究报告了一些人CM骨骼的第一次定量I.ICT数据，这表明对OI骨骼评估的未来令人信服的可能性。

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