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首页> 外文会议>SPIE Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Preliminary Clinical Results: An Analyzing Tool for 2D OpticalImaging in Detection of Active Inflammation in Rheumatoid Arthritis
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Preliminary Clinical Results: An Analyzing Tool for 2D OpticalImaging in Detection of Active Inflammation in Rheumatoid Arthritis

机译：初步临床效果：用于检测类风湿性关节炎中活性炎症中的2D耐注的分析工具

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Optical imaging (OI) is a relatively new method in detecting active inflammation of hand joints of patients suffering from rheumatoid arthritis (RA). With the high number of people affected by this disease especially in western countries, the availability of OI as an early diagnostic imaging method is clinically highly relevant. In this paper, we present a newly in-house developed OI analyzing tool and a clinical evaluation study. Our analyzing tool extends the capability of existing OI tools. We include many features in the tool, such as region-based image analysis, hyper perfusion curve analysis, and multi-modality image fusion to aid clinicians in localizing and determining the intensity of inflammation in joints. Additionally, image data management options, such as the full integration of PACS/RIS, are included. In our clinical study we demonstrate how CH facilitates the detection of active inflammation in rheumatoid arthritis. The preliminary clinical results indicate a sensitivity of 43.5%, a specificity of 80.3%, an accuracy of 65.7%, a positive predictive value of 76.6%, and a negative predictive value of 64.9% in relation to clinical results from MRI. The accuracy of inflammation detection serves as evidence to the potential of OI as a useful imaging modality for early detection of active inflammation in patients with rheumatoid arthritis. With our in-house developed tool we extend the usefulness of OI imaging in the clinical arena. Overall, we show that OI is a fast, inexpensive, non-invasive and non-ionizing yet highly sensitive and accurate imaging modality.
机译：光学成像（OI）是检测患有类风湿性关节炎（RA）的患者手关节的活性炎症的相对较新的方法。随着受该疾病影响的大量受此疾病的影响，特别是在西方国家，作为早期诊断成像方法的可用性是临床高度相关的。在本文中，我们在新内部开发的OI分析工具和临床评估研究。我们的分析工具扩展了现有OI工具的能力。我们在工具中包括许多特征，例如基于区域的图像分析，超灌注曲线分析和多模态图像融合，以帮助临床医生定位和确定关节中炎症的强度。此外，还包括图像数据管理选项，例如PACS / RIS的完整集成。在我们的临床研究中，我们展示了CH如何利用类风湿性关节炎的激活炎症。初步临床结果表明43.5％的灵敏度，80.3％的特异性，65.7％的精确度，76.6％的阳性预测值和64.9％相对于从MRI的临床结果，阴性预测值。炎症检测的准确性是oi作为用于早期检测类风湿性关节炎患者的有用的成像模型的潜力的证据。通过我们内部开发的工具，我们在临床竞技场中扩展了OI成像的有用性。总体而言，我们表明OI是一种快速，廉价，无侵入性和非电离且高度敏感的和精确的成像模态。

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