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HIGH CAPACITY COUNTERCURRENT CHROMATOGRAPHY FOR FAST ISOLATION OFNATURAL PRODUCTS

机译:高容量逆流色谱法,用于快速隔离

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Countercurrent chromatography (CCC) is a technique that was first invented in the mid 1960's. After a brief period of interest by many scientists, the technique declined in popularity, being effectively out-competed by rival techniques that were faster and more reliable. To many, CCC was known as a slow technique with separations measured in hours or days, with poor capacity allowing injections of only tens of milligrams, poor reliability and difficult scale-up because of a poor understanding of the factors required to scale up or instruments on which to do so. However, recent engineering improvements and advances in the understanding of the process have transformed the technique to one which provides separations in minutes, injection loadings in the scale of grams to hundreds-of-grams, equipment that is considerably more robust and a scale up from analytical to pilot level that is quick and easy.
机译:逆流色谱(CCC)是在1960年代中期首次发明的技术。在许多科学家们简短的兴趣之后,该技术越来越受欢迎,通过竞争力的技术有效地竞争,这些技术更快,更可靠。对于许多人来说,CCC被称为慢速技术,在数小时或几天中测量分离,容量差,允许注射几十毫克,可靠性差和困难扩大,因为对所需的因素或仪器所需的因素较差这样做。然而,最近的工程改进和对过程的理解进步已经将该技术转化为在几分钟内提供分离,注射载荷的注射载荷为数百克,设备比较强大,从而增加分析到飞行员水平,即快速且容易。

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