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首页> 外文会议>International Conference on Recent Trends in Materials and Mechanical Engineering >Development and Application of Tandem LC-MS Method for the Determination of Paralytic Shellfish Poisoning Toxins for Pollution Monitoring
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Development and Application of Tandem LC-MS Method for the Determination of Paralytic Shellfish Poisoning Toxins for Pollution Monitoring

机译：串联LC-MS法测定麻痹性贝类中毒毒素污染监测的发展与应用

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In the present study, the development of the tandem liquid chromatography-mass spectrometry (LC-MS) method for the sensitive and selective determination of eight paralytic shellfish poisoning (PSP) (GTX1, GTX2, GTX3, GTX4, GTX5, dcGTX2, dcGTX3 and dcNEO-b) toxins was investigated. Various experimental factors affecting the pretreatment and LC-MS procedures were optimzed, respectively. Using slected reaction monitoring (SRM) mode in LC-MS analysis, the acquired calibration curves were strictly linear with the value of r~2 more than 0.996 for the eight targeted analyses. The obtained data expressed as relative standard deviations (RSDs), for the within-laboratory reproducibility and repeatability were less than 6.9% and 7.9%, respectively. The feasibility of the proposed method was finally validated by analyzing the eight PSPs in shellfish samples from diverse Chinese sea areas for the quality assurance of the aquatic producs and enviroment protection monitoring.
机译：在本研究中，串联液相色谱 - 质谱（LC-MS）方法的敏感和选择性测定八个麻痹贝类中毒（PSP）（GTX1，GTX2，GTX3，GTX4，GTX5，DCGTX2，DCGTX3和调查了DCNEO-B）毒素。影响影响预处理和LC-MS程序的各种实验因素。在LC-MS分析中使用加入反应监测（SRM）模式，所获得的校准曲线严格线性，对于八个目标分析，R〜2的值超过0.996。所获得的数据表达为相对标准偏差（RSD），用于实验室的再现性和可重复性分别小于6.9％和7.9％。最终通过分析来自不同中国海域的贝类样本中的八个PSP来验证所提出的方法的可行性，以获得水生产品生产和环境保护监测的质量保证。

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