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Development of Bisphosphonate-Calcium Phosphate Composites and Drug Release Characteristic

机译：双膦酸盐 - 磷酸钙复合材料和药物释放特性的研制

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Bisphosphonate (Bp) was adsorbed on the surface of crystalline calcium phosphates (CP); hydroxyapatite (HAp), octacalcium phosphate (OCP) and Dicalcium phosphate dehydrate (DCPD). The amount of Bp adsorbed was the largest for DCPD per unit surface area, while the amount was the largest for HAp per unit weight. The composites of Bp and amorphous calcium phosphate (ACP) were synthesized by titrating calcium acetate solution into phosphate buffer solution containing Bp. The amount of Bp doped in the composites was 366 μg / mg and was approximately 7 times larger than those of Bp adsorbed on the crystalline Calcium phosphates. TG-DTA measurements of a Bp-calcium and the composite indicated exothermic peaks due to Bp combustion, of which temperature were shifted to higher temperature for the composite. Bp in the composites was gradually released into phosphate buffered saline, while Bp was rapidly released into acetate buffer solution accompanied with the dissolution of ACP. This result suggests that the composite of Bp and ACP has potential for a drug-carrier releasing Bp in response to the condition of osteoclastic bone resorption.
机译：Bisphosphonate（BP）吸附在磷酸钙（CP）的表面上;羟基磷灰石（HAP），磷酸叔钯（OCP）和磷酸二钙脱水（DCPD）。吸附的BP量为每单位表面积的DCPD最大，而每单位重量的HAP量最大。通过将醋酸钙溶液滴定到含有BP的磷酸盐缓冲溶液中，合成BP和非晶磷酸钙（ACP）的复合材料。复合材料中掺杂的BP的量为366μg/ mg，比吸附在结晶磷酸钙上的BP大约7倍。由于BP燃烧，BP钙和复合材料的TG-DTA测量结果表明了温度燃烧的放热峰，以将温度移位至复合材料的较高温度。复合材料中的BP逐渐释放到磷酸盐缓冲盐水中，而BP伴随着伴随ACP的溶解将BP释放到乙酸盐缓冲溶液中。该结果表明，BP和ACP的复合材料具有促进BP的药物载体的潜力，响应于骨细胞骨吸收的状况。

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