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首页> 外文会议>International Conference on Wearable Micro and Nano Technologies for Personalized Health >Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment
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Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment

机译：口腔/床边诊断口腔和呼吸道感染，以及鉴别个性化监测和治疗的抗生素电阻

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Global healthcare systems are struggling with the enormous burden associated with infectious diseases, as well as the incessant rise of antimicrobial resistance. In order to adequately address these issues, there is an urgent need for rapid and accurate infectious disease diagnostics. The H2020 project DIAGORAS aims at diagnosing oral and respiratory tract infections using a fully integrated, automated and user-friendly platform for physicians' offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, dental caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalised monitoring. Respiratory Tract Infections will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial or viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated processing device) integrating all components and assays for a fully automated analysis. The project involves an interface with a clinical algorithm for the comprehensive presentation of results to end-users, thereby increasing the platform's clinical utility. DIAGORAS' performance will be validated at clinical settings and compared with gold standards.
机译：全球医疗保健系统正在努力与传染病相关的巨大负担，以及抗微生物抗性的不停的兴起。为了充分解决这些问题，迫切需要快速准确的传染病诊断。 H2020项目Diagoras旨在使用全面的，自动和用户友好的医生办公室，学校，老年护理单位，社区环境等的完全集成，自动和用户友好的平台诊断口腔和呼吸道感染。将被检测到口服疾病（牙周炎，龋齿）通过复用，定量分析唾液标志物（细菌DNA和宿主响应蛋白）进行早期预防和个性化监测。通过DNA / RNA分化诊断呼吸道感染，以鉴定其细菌或病毒性质。与同一平台上的抗生素抗性筛选在一起，在护理点，预计会更有效的治疗管理。 Diagoras的核心位于离心微流体平台（LabDisk和相关处理设备），整合所有组件和测定以进行全自动分析。该项目涉及具有临床算法的界面，用于综合结果对最终用户的结果，从而增加平台的临床实用。 Diagoras的性能将在临床环境中验证，并与黄金标准进行比较。

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