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首页> 外文会议>Philadelphia, Pennsylvania Meeting >Modeling of DNA Zipper and Zipper Based Spring Reaction Rates
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Modeling of DNA Zipper and Zipper Based Spring Reaction Rates

机译：DNA拉链和拉链弹簧反应速率建模

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摘要

DNA zippers are a thermodynamically driven system consisting of three DNA oligonucleotides. Two of the strands are designed to create a small helix the third is designed to invade and separated the helix. A zipper system consisting of a normal strand (N), a weak strand (W), and an opening strand (O). N is made up of normal DNA bases, while W is engineered with inosine bases substituted for guanine. Inosine forms one less hydrogen bond with cytosine than guanine. By varying the number and order of inosine, W is engineered to provide less than natural bonding affinities to N in forming the [N:W] helix. When O is introduced (a natural complement of N), it competitively displaces W from [N:W] and forms [N:O]. DNA zippers have been used to create new DNA devices such as springs and tweezers and to create functionalized DNA origami structures. Currently, The basic principles and interactions of DNA zippers are not well understood. Here we will report the results on an investigation of several different DNA zipper constructs designed to aid in the creation of a mathematical prediction of the reaction rate for DNA zippers.
机译：DNA拉链是由三种DNA寡核苷酸组成的热力学驱动系统。两个股线旨在创造一个小螺旋，第三个旨在侵入和分离螺旋。由正常链（n），弱链（W）和开口链（O）组成的拉链系统。 n由正常的DNA碱基组成，而W的设计是用血管取代的肌苷碱。毒液与胞嘧啶的氢键形成一个少于鸟嘌呤。通过改变Inosine的数量和顺序，W被设计为在形成[N：W]螺旋中的N时提供少于天然键合亲和力。当介绍O时（n的自然补充），它竞争地争夺从[n：w]的w，并形成[n：o]。 DNA拉链已被用于创建新的DNA设备，例如弹簧和镊子，并产生官能化DNA折纸结构。目前，DNA拉链的基本原理和相互作用并不熟知。在这里，我们将在研究结果上报告旨在帮助创建DNA拉链的反应速率的数学预测的几种不同DNA拉链构建结果。

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