• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Conference on Material Sciences and Technology >Supercritical Fluid Extraction of Polygonum Cuspidatum and Subsequent Isolation by Simulated Moving Bed Chromatography
【24h】

Supercritical Fluid Extraction of Polygonum Cuspidatum and Subsequent Isolation by Simulated Moving Bed Chromatography

机译：浅临界流体萃取聚四糖豆荚和模拟移动床色谱分离的分离

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this work, supercritical carbon dioxide with ethanol as cosolvent was employed to extract bioactive compounds from Polygonum Cuspidatum. Effect of temperature for 40 and 50 C on the extraction at 35 MPa was examined. It was found that extraction at 50 C resulted in high yield. A two-stage extraction at 50 C and 35 MPa was then designed to investigate effect of cosolvent on the recovery of resveratrol and emodin. The first stage extraction by solely using carbon dioxide can rarely extract resveratrol, but adding ethanol as cosolvent in the second stage significantly increases the extraction of resverarol and emodin. The crude extract obtained in the second stage was very stable against agglomeration and precipitation, because the first stage extraction helped to remove impurities from the Polygonum Cuspidatum. The stable crude extract was subsequently used as the feed for the SMB (simulated moving bed) separation. In this work, experimental validation was completed by solely using single SMB to isolate resveratrol, emodin, and physcion from the crude extract. As conducting the SMB experiments, the Triangle theory was used to help to determine the separable operating conditions. From the discussion of the experimental results, the criterion to obtain the pure resveratrol and physcion, and the concentrated emodin were depicted. Since both the extraction and the purification are conducted at low temperature, the bioactivity of the produced natural products will totally be preserved. The two-stage extraction and subsequent purification in this paper will provide greener and effective alternative for the development of botanical drugs.
机译：在这项工作中，使用与乙醇的超临界二氧化碳作为共溶剂，以从聚糖豆荚中提取生物活性化合物。检查温度40和50c对35MPa提取的影响。发现50℃的提取导致产量高。然后设计了50℃和35MPa的两阶段提取，以调查共溶剂对白藜芦醇和大黄素的回收率的影响。通过仅使用二氧化碳的第一阶段提取可以很少提取白藜芦醇，但在第二阶段中加入乙醇，显着增加了白藜芦醇和大黄素的提取。在第二阶段中获得的粗提物抵抗聚集和沉淀非常稳定，因为第一阶段萃取有助于除去来自番茄囊肿的杂质。随后使用稳定的粗提取物作为SMB（模拟移动床）分离的饲料。在这项工作中，通过单独使用单个SMB来分离粗提取物的白藜芦醇，大蛋白和物理学来完成实验验证。作为进行SMB实验，三角形理论用于帮助确定可分离的操作条件。根据实验结果的讨论，描绘了获得纯白藜芦醇和物理的标准和浓缩的大蛋白。由于萃取和净化均在低温下进行，因此产生的天然产物的生物活性将完全保留。本文的两级提取和随后的纯化将为植物药物的发展提供更环保和有效的替代方案。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号