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首页> 外文期刊>The Journal of Supercritical Fluids >Extraction of lignans from the seed of Schisandra chinensis by supercritical fluid extraction and subsequent separation by supercritical fluid simulated moving bed
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Extraction of lignans from the seed of Schisandra chinensis by supercritical fluid extraction and subsequent separation by supercritical fluid simulated moving bed

机译：超临界流体萃取法从五味子种子中提取木脂素，然后用超临界流体模拟移动床分离

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In this study, the lignans in the seed of Schisandra chinensis were extracted by supercritical fluid extraction (SFE), and the lignans in the obtained seed oil were subsequently separated by simulated moving bed (SMB) chromatography with supercritical fluid as the desorbent (SF-SMB). Four lignans: Schisandrol A, Schisandrol B, Schisandrin A and Schisandrin B, in the seed oil are monitored to study the extraction and separation. Effects of the extraction temperature (40-60 degrees C), pressure (20-35 MPa) and the content of ethanol as a cosolvent (0-10.8 wt%) on the yield of seed oil were investigated. Sovova's equation was applied to fit the experimental results to investigate the extraction kinetics. A three-section SMB with six packed columns configured as 2/2/2 was employed to separate the lignans in the seed oil. Preparative silica gel was selected as the adsorbent, and 2-propanol was used as the cosolvent for supercritical carbon dioxide at 40 degrees C and 13.6 MPa. The separation of lignans by the SF-SMB was conducted by creating a slight concentration gradient of 2-propanol (14.8-15.5%) along the six packed columns. The experimental results showed that Schisandrol A with 42.9 wt% and Schisandrin B with 4.34 wt% can be individually separated from the seed oil, and the separation of Schisandrol A and B and Schisandrin A and B was successfully achieved. This study demonstrates that the extraction and separation of bioactive ingredients from herbs can be finished by solely using the supercritical fluid related technologies. (C) 2015 Elsevier B.V. All rights reserved.
机译：本研究中，五味子种子中的木脂素通过超临界流体萃取（SFE）提取，然后将获得的种子油中的木脂素通过模拟移动床（SMB）色谱法进行分离，其中超临界流体作为解吸剂（SF- SMB）。监测种子油中的四种木酚素：五味子酚A，五味子酚B，五味子素A和五味子素B，以研究提取和分离。研究了萃取温度（40-60℃），压力（20-35 MPa）和乙醇助溶剂含量（0-10.8 wt％）对种子油收率的影响。应用Sovova方程拟合实验结果以研究萃取动力学。采用三节SMB，将六根填充柱配置为2/2/2，以分离种子油中的木脂素。选择制备硅胶作为吸附剂，并在40摄氏度和13.6 MPa下使用2-丙醇作为超临界二氧化碳的助溶剂。 SF-SMB分离木脂素的方法是沿六个填充塔产生2-丙醇（14.8-15.5％）的轻微浓度梯度。实验结果表明，可以从种子油中分别分离出42.9 wt％的五味子酚A和4.34 wt％的五味子素B，成功实现了五味子酚A和B以及五味子素A和B的分离。这项研究表明，仅通过使用超临界流体相关技术就可以完成从草药中提取和分离生物活性成分的工作。 （C）2015 Elsevier B.V.保留所有权利。

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