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首页> 外文会议>NATO Advanced Research Workshop on Radiological Issues Pertaining to Environmental Security and Ecoterrorism >Direct and Reverse Bystander Effect Between Irradiated and Unirradiated Organisms: The Modulating Role of Chemosignalling in Ecology
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Direct and Reverse Bystander Effect Between Irradiated and Unirradiated Organisms: The Modulating Role of Chemosignalling in Ecology

机译：辐照和未照射生物之间的直接和逆向旁观者效应：化学所有人在生态中的调节作用

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It was shown that mice or rats exposed to sublethal dose of ionizing radiation are able to decrease the immune reactivity of intact animals when them kept together in the same cage. Even one individual can cause such a disturbances of immunity in a group of intact animals. The data indicate that at early stage after exposure to sublethal doses of ionizing radiation mice secrete volatile components (VC) in urine which decreased thymus dependent humoral immune response in intact animals (to 60-70% relative control). The stable effect observed as a result of 1-day exposure allowed us to study the time course of secretion of immunosuppressive VC by irradiated animals. These VC possess attractive properties for the intact individuals. The irradiated mice showed an increased attractiveness to intact individuals. The biological significance of a combination of the immunosuppressive and attractive effects of VC is unclear. It is supposed, that mammals possess of the distant immunomodulating chemosignal system, aimed at the immunoreactivity of individuals with immunodeficiency state. It was established that VC of intact mice restored the humoral immune response and other parameters of immunity in irradiated with a dose of 1 Gy animals. In this case, the irradiated recipients demonstrated an increase of humoral immune response to 140-170%. These VC of intact mice activated at irradiation mice phagocytic activity peritoneal macrophages. Exposure of rats for the third day after irradiation This work was supported by the Russian Foundation for Basic Research and the Government of (1 Gy) to the VC of intact animals significantly increased the number of red blood cells, lymphocytes and granulocytes in the bloodstream. Thus, direct and reverse bystander chemosignaling between the irradiated and intact, irradiated and irradiated animals mediate the modification of immunity and behavioral reactions of recipients. Apparently these untargeted effects of radiation spreading from one individual to another can have a significant impact on the viability of the entire population of animals.
机译：结果表明，暴露于亚致死的电离辐射的小鼠或大鼠能够在同一笼子保持在一起时降低完整动物的免疫反应性。甚至一个人甚至一个人都会导致一组完整的动物中的免疫扰动。数据表明，在暴露于亚致亚致抗辐射小鼠的早期阶段，尿液中的挥发性组分（Vc）在完整的动物中减少胸腺依赖性体液免疫反应（相对控制60-70％）。由于1天暴露而观察到的稳定效果使我们能够研究辐照动物的免疫抑制VC的分泌时间过程。这些VC对完整的个人具有有吸引力的性质。辐照的小鼠表现出对完整个体的吸引力增加。免疫抑制和VC对VC有吸引力的组合的生物学意义尚不清楚。假设是，哺乳动物具有远处免疫调节化学型系统，旨在具有免疫缺陷状态的个体的免疫反应性。建立了完整小鼠的VC恢复了辐照动物的体液免疫应答和其他抗扰度参数。在这种情况下，辐照的受体证明了体液免疫应答的增加至140-170％。这些完整小鼠的VC在吞噬小鼠吞噬活动腹膜巨噬细胞中激活。在照射后第三天的大鼠暴露这项工作得到了俄罗斯基础研究基础的支持，（1 GY）的政府对完整动物的VC的影响显着增加了血液中的红细胞，淋巴细胞和粒细胞的数量。因此，在照射和完整，辐照和辐照动物之间的直接和反向旁观者化学介导介导受试者的免疫和行为反应的改性。显然，从一个个体到另一个人的辐射蔓延的这些无明确的影响可能对整个动物群体的活力产生重大影响。

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