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首页> 外文会议>International Conference on Eco-Dyeing, Finishing and Green Chemistry >Antibacterial Efficiency and Cellular Toxicity of PET-based Hollow Fibers Containing Silver Particles
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Antibacterial Efficiency and Cellular Toxicity of PET-based Hollow Fibers Containing Silver Particles

机译：含银颗粒的PET基中空纤维的抗菌效率和细胞毒性

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摘要

This work focuses on antibacterial efficacy and cellular toxicity of PET-based hollow fiber with silver particles incorporated (Ag/PET hollow fiber), which was synthesized by differential pressure method. Escherichia coli (E. coli) were used to investigate the antibacterial capability of Ag/PET hollow fiber with antibacterial kinetics experiments. The antibacterial results demonstrated that Ag/PET hollow fiber had an excellent antibacterial property against E. coli and the efficacy was dependent on several aspects including fiber length, weight and silver content. The cytotoxicity of Ag/PET hollow fibers on WI-38 cells was assessed using Methyl Thiazolyl Tetrazolium (MTT) assay, and the results showed no significant toxicity to WI-38 cells. SEM images of WI-38 cells treated by Ag/PET hollow fibers showed that cells morphology was unaltered in the presence of Ag/PET hollow fiber. However, abnormal size, shrinkage and rounded appearance of cells at higher dose suggested slight toxicity of Ag/PET hollow fiber. Combining the antibacterial and cytotoxic results, it was found that there was a certain concentration of silver ions which can achieve a minimization of cytotoxicity and a maximization of antibacterial efficacy.
机译：该工作侧重于PET基中空纤维的抗菌效力和细胞毒性，其掺入的银颗粒（Ag / Pet中空纤维），通过差压方法合成。大肠杆菌（大肠杆菌）用于研究AG / PET中空纤维与抗菌动力学实验的抗菌性能力。抗菌结果表明，AG / PET中空纤维对大肠杆菌具有优异的抗菌性，并且功效取决于包括纤维长度，重量和银含量的若干方面。使用甲基噻唑基四唑（MTT）测定评估Wi-38细胞上的Ag / PET中空纤维的细胞毒性，结果表明对WI-38细胞没有显着的毒性。 AG / PET中空纤维处理的WI-38细胞的SEM图像显示，在AG / PET中空纤维的存在下，细胞形态未妨碍。然而，在较高剂量下细胞的异常尺寸，收缩和圆形外观表明Ag / Pet中空纤维的轻微毒性。结合抗菌和细胞毒性结果，发现存在一定浓度的银离子，其​​可以实现细胞毒性的最小化和抗菌效力的最大化。

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