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首页> 外文会议>International Symposium on Ocular Pharmacology and Therapeutics >Changes in Intraocular Pressure, Ocular Perfusion Pressure and Blood Flow Fluctuations during Dorzolamide vs Timolol Add-on Therapies in Glaucoma Patients Previously Treated with Prostaglandin Analogue
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Changes in Intraocular Pressure, Ocular Perfusion Pressure and Blood Flow Fluctuations during Dorzolamide vs Timolol Add-on Therapies in Glaucoma Patients Previously Treated with Prostaglandin Analogue

机译：在先前用前列腺素类似物治疗的高唑胺患者中的眼压力，眼灌注压力和血流波动的变化，蒂莫尔氏菌患者疗法

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摘要

Glaucoma is an optic neuropathy that continues to amass evidence of its multifac-torial nature. Glaucoma specialists should also consider vascular factors, fluctuation in physiological parameters and neurogenic theories of glaucomatous damage. The aim of this study was to evaluate fluctuations in IOP, blood pressure (BP), ocular perfusion pressure (OPP) and retrobular blood flow comparing the effects of dorzolamide and timolol add-on therapies in open-angle glaucoma patients. Results indicate both add-on therapies significantly lowered IOP compared to latanoprost baseline, with a larger reduction with timolol. Fluctuations of OPP were dependent upon BP but not IOP fluctuations. Lower evening diastolic BP was linked to increased vascular resistivity in the central retinal artery.
机译：青光眼是一种光学神经病变，继续积累其多重性的性质。 青光眼专家还应考虑血管因子，在生理参数和神经源性损伤的神经源性理论中波动。 该研究的目的是评估IOP，血压（BP），眼灌注压力（OPP）和转移血流量的波动，比较Dorzolamide和Timolol附加疗法在开放角度荧光眼患者中的影响。 结果表明，与拉坦斯克斯特基线相比，附加疗法显着降低了IOP，蒂莫尔较大减少。 opp的波动依赖于BP但不是IOP波动。 低夜间舒张BP与中央视网膜动脉中的血管电阻率增加有关。

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