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Epigenetic-regulated microRNAs in glioblastoma and ovarian cancers

机译：胶质母细胞瘤和卵巢癌中的表观遗传调节的microRNA

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Cancer is both a genetic and an epigenetic disease. It is known that carcinogens can induce genetic damage or mutation cause cancer formation. Aberrant microRNA (miRNA) and epigenetic regulation offer an additional layer of explanation along with genetics, which can give a better understanding of the whole carcinogenesis process. In this study, glioblastoma and ovarian cancers are selected for studying the epigenetic mechanism. To investigate the epigenetic issue, DNA methylation, gene and miRNA expression data are employed. Gene expression and methylation of the whole genomic CpG sites are classified into three catalogues: i.e. under, moderate and over. The sets of under and over expressed genes are collected and their miRNA regulators are identified using the miRTarBase database. Genomic information for CpG islands and miRNAs are combined with methylation sites data. Cancer genes (both oncogenes and tumor suppressor genes) are retrieved from three different resources. Our results identified several epigenetic-regulated miRNAs events, which may potentially cause glioblastoma and ovarian cancers. A web-based interface has been set up for query, which can be accessed at http://ppi.bioinfo.asia.edu.tw/ER microRNA.
机译：癌症是遗传和表观疾病。众所周知，致癌物可诱导遗传损伤或突变导致癌症形成。异常的microRNA（miRNA）和表观遗传调节提供了另外的解释以及遗传学，可以更好地了解整个致癌过程。在本研究中，选择胶质母细胞瘤和卵巢癌以研究表观遗传机制。为了研究表观遗传问题，使用DNA甲基化，基因和miRNA表达数据。将整个基因组CpG位点的基因表达和甲基化分为三种目录：即，在中等和过度下。收集和过度表达基因的组，并使用Mirtarbase数据库识别它们的miRNA调节剂。 CPG岛和MIRNA的基因组信息与甲基化网站数据相结合。从三种不同的资源中检索癌症基因（癌肠和肿瘤抑制基因）。我们的结果确定了几种表观遗传监管的MiRNA活动，可能导致胶质母细胞瘤和卵巢癌。已经为查询设置了基于Web的界面，可以访问http://ppi.bioinfo.asia.edu.tw/er microRNA。

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