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首页> 外文会议>UKM FST Postgraduate Colloquium >Prevalence of Lactose Intolerance and its Relation with Bone Mineral Density among Malay Students of Universiti Kebangsaan Malaysia, Malaysia
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Prevalence of Lactose Intolerance and its Relation with Bone Mineral Density among Malay Students of Universiti Kebangsaan Malaysia, Malaysia

机译：马来西亚大学马来语学生乳糖不耐受及其与骨密度的关系

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Lactose intolerance (LI), a risk factor for low bone mineral density (BMD), is the most common type of carbohydrate intolerance, which predominantly affects Southeast Asian populations. However, data on tlie prevalence of LI and its association with BMD among Malaysian adults are still lacking as not much research has been done on this matter. Thus, tlie aims of this study are to detennine the prevalence of LI and to evaluate its association with BMD among students of Universiti Kebangsaan Malaysia. A total of 100 Malay students (50 males and 50 females) with mean age of 23.9 ± 4.7 years old and body mass index of 24.5 ± 5.8 kg/nr were selected to involve in this preliminary study. After an overnight fast, subjects were asked to perfonn hydrogen breath test (HBT) and lactose tolerance test (LTT) after an intake of 300 ml lactose drink (50g lactose). HBT measurements were recorded at every 30 minutes intervals while LTT results were recorded at fasting and 30 minutes after lactose consumption. Visual analogue scales were used to measure gastrointestinal symptoms. BMD was measured at calcaneus bone using quantitative ultrasound and expressed as T-score. A consistent rise by>20 ppm for HBT and failure of blood sugar to rise by >1.10 mmol/L above basal level were considered as abnonnal HBT and LTT. Lactose malabsorption (LM) is defined by abnonnal HBT and LTT whilst LI is characterized by having abnonnal HBT, LTT and gastrointestinal symptoms. Tlie result showed that 86% male and 90% female subjects exhaled breath hydrogen>20 ppm but there was no significant difference (p>0.05) between them. LTT results showed that 86% male subjects failed to rise their blood sugar level>1.10 mmol/L compared to 60% in female subjects. Both male and female subjects had high percentage occunence of gastrointestinal symptom (82 % and 80% respectively) although no significant difference (p>0.05) was demonstrated. Tlie prevalence of LI and LM among all subjects was 77% and 18% respectively but no significant difference (p>0.05) between genders. In contrast, only 5% of the subjects were lactose tolerance. Male subjects were found to have significantly higher (p<0.05) T- score (1.32 ± 1.52) compared to female subjects (0.75 ± 1.22). However, no significant (p=0.264) association between LI and BMD was shown in this study. To conclude, LI does not directly influence BMD. However, reduce calcium intake from milk and milk products due to avoidance of LI could lead to reduce BMD and osteoporosis in tlie long tenn. Therefore, corrective measures should be taken to encourage Malaysian population to increase tlie intake of milk and milk products.
机译：乳糖不耐受（Li），低骨矿物密度（BMD）的危险因素，是最常见的碳水化合物不耐受性，主要影响东南亚人群。然而，关于李的Tlie普遍性及其与马来西亚成年人的BMD的关系仍然缺乏对此事的研究缺乏。因此，这项研究的TLIE目的是确定李的普遍存在，并在凯班达安马华大学学生中评估其与BMD的关联。共有100名Malay学生（50名男性和50名女性），平均年龄为23.9±4.7岁，体重指数为24.5±5.8千克/ NR涉及该初步研究。快速过夜后，在摄入300ml乳糖饮料（50g乳糖）后，要求受试者妥善氢气呼吸试验（HBT）和乳糖耐受试验（LTT）。在每30分钟的间隔时记录HBT测量，同时LTT结果在禁食时记录，乳糖消耗后30分钟。视觉模拟尺度用于测量胃肠道症状。使用定量超声并表示为Calcaneus骨骼测量BMD，表达为T分数。通过> 1.10mmol / L以上基础水平升高的HBT和血糖失败的HBT和血糖失败的一致上升被认为是Abnonnal HBT和LTT。乳糖不吸收（LM）由Abnonnal HBT和LTT定义，而LI的特征在于具有Abnonnal HBT，LTT和胃肠道症状。 TLIE结果表明，86％的男性和90％的女性受试者呼出呼吸氢气> 20 ppm但它们之间没有显着差异（p> 0.05）。 LTT结果表明，86％的男性受试者未能上升其血糖水平> 1.10mmol / L，而女性受试者的60％。雄性和女性受试者都有高百分比的胃肠道症状（分别为82％和80％），尽管证明没有显着差异（P> 0.05）。所有受试者中LI和LM的患病率分别为77％和18％，但在线均无显着差异（P> 0.05）。相比之下，只有5％的受试者是乳糖耐受性。与女性受试者相比，发现男性受试者显着更高（P <0.05）T-得分（1.32±1.52）（0.75±1.22）。然而，本研究显示了Li和BMD之间的显着（p = 0.264）关联。结论，李不直接影响BMD。然而，由于避免锂而降低牛奶和牛奶产品的钙进口可能导致在Tlie Long Tenn中降低BMD和骨质疏松症。因此，应采取纠正措施来鼓励马来西亚人口增加牛奶和牛奶产品的TLIE摄入量。

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