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首页> 外文会议>IMEKO TC13 Symposium on Measurements in Biology and Medicine >COMPARISON BETWEEN ULTRASOUND FRAGILITY SCORE AND FRAX FOR THE ASSESSMENT OF OSTEOPOROTIC FRACTURE RISK
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COMPARISON BETWEEN ULTRASOUND FRAGILITY SCORE AND FRAX FOR THE ASSESSMENT OF OSTEOPOROTIC FRACTURE RISK

机译：超声脆性评分与骨折评分的比较，用于评估骨质疏松骨折风险

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The assessment of osteoporotic fracture risk requires the measurement of bone mineral density (BMD) on reference sites (hip and spine) and the evaluation of clinical risk factors (CRFs) for fracture. The Fracture Risk Assessment algorithm (FRAX), internationally recognized by official guidelines for osteoporotic patient management, represents a tool for estimating 10-year probability of hip and major fragility fractures by integrating CRFs and femoral neck BMD or T-score, when available. In this work we presented an innovative ultrasound (US)-based method for estimating fracture risk by means of a safe and radiation-free approach. From abdominal ultrasound scans performed on 64 female patients, we defined and quantified a new US diagnostic parameter named Fragility Score (F.S.), which estimates bone fragility. Obtained results showed an high Pearson correlation coefficient between fracture probabilities calculated by FRAX and F.S. (r up to 0.75 in the case of FRAX estimates including femoral neck BMD and r=0.71 in the case of FRAX estimates based on femoral neck T-score). The present study demonstrated the feasibility of a novel US approach for fracture risk prediction and prevention, directly applicable on spine and independent from BMD measurements and CRF assessments. The proposed methodology could represent a valid alternative to both FRAX and BMD for early assessment of fracture risk.
机译：骨质疏松性骨折风险的评估需要在参考地点（髋部和脊柱）上的骨密度（BMD）的测量和对骨折的临床风险因素（CRF）的评价。骨折风险评估算法（FRAX）是通过骨质疏松患者管理官方认可的国际认可，代表了一种用于估算髋关节和主要脆弱性骨折概率的工具，通过整合CRF和股骨颈部BMD或T-Score可用。在这项工作中，我们通过安全和无辐射方法介绍了一种创新的超声（美国）基础的方法，用于估计骨折风险。从64名女性患者进行的腹部超声扫描，我们定义和量化了一个名为脆弱评分（F.S.）的新美国诊断参数，估计骨脆性。获得的结果显示了通过Frax和F.S的裂缝概率之间的高Pearson相关系数。 （r高达0.75在股骨颈BMD和r = 0.71的FRAX估计的情况下，在基于股骨颈T评分的Frax估计的情况下）。本研究表明，新型美国裂缝风险预测和预防方法的可行性，直接适用于脊柱，独立于BMD测量和CRF评估。所提出的方法可以代表Frax和BMD的有效替代方案，用于早期评估骨折风险。

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