Synthesis of 2-((4-Substituted Phenyl) Amino) Benzaldehyde

机译：合成2 - （（4-取代的苯基）氨基）苯甲醛

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2-((4-substituted phenyl) amino) benzaldehyde, is an important intermediate for the synthesis of many biologically active intermediates of anticancer drugs. In this work, a rapid and high efficiency synthetic method for compound 1a-1b was established. Compound 1a-1b was synthesized from 2-chloronicotinic acid and 4-substituted anilines through three steps including nucleophilic substitution, reduction and oxidation reaction. The structure of the target compound 1a-1b was confirmed by H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 59.49%.

机译：2 - （（4-取代的苯基）氨基）苯甲醛，是合成抗癌药物许多生物活性中间体的重要中间中间体。在这项工作中，建立了一种快速和高效的化合物1A-1B的合成方法。通过包括亲核取代，还原和氧化反应的三个步骤，通过三个步骤合成化合物1A-1B。通过H NMR和MS光谱证实了目标化合物1A-1B的结构。此外，优化了合成方法。三个步骤的总产量为59.49％。

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《International Conference on Electronics, Mechanics, Culture and Medicine》|2017年|709-1415p|共4页
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Yongli Duan; Zhimin Li; Qidong Tang; Rui Li; Shan Xu;
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中图分类 TN-53;
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2-((4-substituted phenyl) amino) benzaldehyde; Synthesis; Process optimization;

机译：2 - （（4-取代的苯基）氨基）苯甲醛;合成;过程优化;

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1. A Linear Solvation Energy Relationship Study for the Reactivity of 2-(4-Substituted Phenyl)- cyclohex-1-enecarboxylic,2-(4-Substituted Phenyl)-benzoic, and 2-(4-Substituted Phenyl)-acrylic Acids with Diazodiphenylmethane in Various Solvents [J] . I. B. NIKOLIC, G. S. USCUMLIC, I. O. JURANIC International Journal of Chemical Kinetics . 2010,第7期

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2. Microwave-assisted synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-amino-6-(4-substituted phenyl)-pyrimidin-4-yl)-phenoxy)-2- methyl propanoic acid derivatives [J] . MokaleS.N., ElgireR.D., SakleN.S., Archiv der Pharmazie . 2012,第1期

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4. Synthesis of 2-((4-Substituted Phenyl) Amino) Benzaldehyde [C] . Yongli Duan, Zhimin Li, Qidong Tang, International Conference on Electronics, Mechanics, Culture and Medicine . 2017

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Synthesis of 2-((4-Substituted Phenyl) Amino) Benzaldehyde

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