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首页> 外文会议>International Conference on Biological Science >The influence of mackerel fish (Rastrelliger sp.) consumption towards the number of pyramidal cell in cerebral cortex of congenital hypothyroid rats (Rattus norvegicus)
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The influence of mackerel fish (Rastrelliger sp.) consumption towards the number of pyramidal cell in cerebral cortex of congenital hypothyroid rats (Rattus norvegicus)

机译：鲭鱼（Rastrelliger sp.）消费对先天性甲状腺大鼠脑皮质锥形术细胞数量的影响（rattus norvegicus）

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Congenital hypothyroid is a congenital endocrine disorder that occurs most commonly in childhood and a common cause of preventable mental retardation. Hypothyroidism can cause brain cells damage. Previous studies showed that omega-3 has a role as a neuroprotective agent. Indian mackerel fish have been selected for having higher omega-3 compared to fishes commonly consumed in Indonesia. The purpose of this study is to know the effect of mackerel fish (Rastrelliger sp.) consumption toward the number of pyramidal cells in the cerebral cortex of the congenital hypothyroid rat. An experimental study with the posttest-only control group design was done in 30 Sprague-Dawley rats that were divided into six groups. Four groups were induced by PTU for 5 d of gestation until 15 d of neonates, and two other groups were not induced. Thyroxine and mackerel were given on 21 d of birth until 8 wk. Later, rat's brain was taken for histology preparation with HE staining and cerebral cortex pyramidal cells observation under a light microscope. The data were analyzed using statistic test of One Way ANOVA. The average number of pyramidal cells in cerebral cortex in each group; positive control, normal with mackerel, hypothyroid, hypothyroid with mackerel, hypothyroid with thyroxine, and hypothyroid with mackerel and thyroxine were 117 ± 18, 146 ± 24, 55 ± 6, 115 ± 6, 83 ± 3 and 100 ± 9 per field of vision, respectively. The statistic test showed a significant result (p < 0.05). There was an effect of giving Indian mackerel to the pyramidal cells in the cerebral cortex of the congenital hypothyroid rat.
机译：先天性甲状管是一种先天性内分泌紊乱，最常见于儿童，以及可预防的精神病迟滞的常见原因。甲状腺功能减退症会导致脑细胞损坏。以前的研究表明，Omega-3具有作为神经保护剂的作用。与印度尼西亚通常消耗的鱼类相比，印度鲭鱼鱼已被选为较高的ω-3。本研究的目的是了解鲭鱼鱼（Rastrelliger sp。）消耗朝向先天性甲状腺细胞大鼠脑皮质中的金字塔细胞数量的影响。在30次Sprague-Dawley大鼠中进行了唯一只有唯一对照组设计的实验研究，分为六组。 PTU诱导了四组诱导5D妊娠，直至15 d新生儿，另外两组未诱导。甲状腺素和鲭鱼在出生之前给出直到8周。后来，用HE染色和脑皮质金字塔孔细胞在光学显微镜下观察，对组织学准备进行大鼠的大脑。使用单向ANOVA的统计测试分析数据。每组脑皮层中的金字塔孔细胞的平均数量;阳性对照，用鲭鱼，甲状腺功能亢进，用鲭鱼，甲状腺素，甲状腺素，甲状腺素和甲状腺素和甲状腺素的甲状腺功能率为117±18，146±24,55±6，115±6，83±3和100±9平方米视觉分别。统计测试显示出显着的结果（P <0.05）。将印度鲭鱼在先天性甲状腺功能率大鼠的脑皮质中给金字塔细胞给予仿制效果。

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