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首页> 外文会议>International Conference on Biological Science >Cytotoxic effects and apoptosis of solo black garlic (Allium sativum L.) extract on T47D breast cancer cell line
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Cytotoxic effects and apoptosis of solo black garlic (Allium sativum L.) extract on T47D breast cancer cell line

机译：T47D乳腺癌细胞中Solo黑色大蒜（Allium Sativum L.）提取物的细胞毒性作用及凋亡

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摘要

Breast cancer frequently occurs to woman and at least there are 1.67 million cases of breast cancer in 2012. One of alternative medications which is relatively cheap and without side effect is the use of single black garlic. The activity of anti-cancer on single black garlic can pass the apoptosis path which causes cancer cell to be dead and anti- proliferation path which causes the growth of cancer cell to be inhibited. This research aims to study the effect solo black garlic extract (hexane, chloroform, ethyl acetate) towards the breast cancer cell T47D. The method used in this research was extraction, freeze drying to prepare the sample, MTT Assay to examine the cytotoxicity and also Flow-cytometry to the test of apoptosis cell T47D. The result of the cytocytoxity test known that there kinds of extract which have potency to decrease the viability percentage of cell T47D which is more than 50% in the concentration less than 2000 μg/ml, that is single black garlic's hexane as much 1.558 μg/ml, chloroform as much 658μl, and extract of ethyl acetate of single black garlic as much 551 μg/ml. The result of apoptosis test shows that the extract of single black garlic has potency towards the induction of apoptosis cell T47D.
机译：乳腺癌经常发生在女人身上，2012年至少有1.67亿例乳腺癌。相对便宜，没有副作用的替代药物之一是使用单黑色大蒜。抗癌在单黑大蒜上的活性可以通过凋亡途径，这导致癌细胞死亡和抗增殖路径，导致癌细胞的生长被抑制。本研究旨在研究抗乳腺癌细胞T47D的独奏黑色大蒜提取物（己烷，氯仿，乙酸乙酯）。本研究中使用的方法是提取的，冷冻干燥以制备样品，MTT测定以检查细胞毒性，还对凋亡细胞T47D的试验进行流量毒性。已知细胞细胞毒性测试的结果，具有降低细胞T47D的可行性百分比的效力的提取物，其浓度小于2000μg/ ml，即单颗黑色大蒜的己烷为1.558μg/ ml，氯仿多达658μl，并提取单黑色大蒜乙酸乙酯，多达551μg/ ml。细胞凋亡试验的结果表明，单黑色大蒜提取物对凋亡细胞T47D的诱导具有效力。

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