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首页> 外文会议>Joint Conference on Chemisty >HLA-DP, HLA-DQ, and HLA-DR-restricted epitopes in GRA5 of toxoplasma gondii strains
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HLA-DP, HLA-DQ, and HLA-DR-restricted epitopes in GRA5 of toxoplasma gondii strains

机译：HLA-DP，HLA-DQ和HLA-DR限制表位在弓形虫Gondii菌株的Gra5中

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The dense granular (GRA) proteins of Toxoplasma gondii(T. gondii) have been demonstrated as potential sources of T. gondii vaccine antigens. However, data of the GRA5 protein are limited. This study analyzed twenty-one complete GRA5 sequences of T. gondii GT1, RH, ME49, VEG, MAS, RUB, FOU, p89, VAND, and GAB2-2007-GAL-DOM2 strains to identify potential epitopes restricted by Major Histocompatibility Complex class II (MHC-II) molecules (human leukocyte antigen (HLA)-DP, HLA-DQ, and HLA-DR) in the protein. In all T. gondii strains, peptides positioned at amino acid (aa) 15-29, 16-30, 17-31, 18-32, 19-33, 83-97, 84-98, 86-100, 87-101, 89-103, and 90-104 were predicted to pose high affinity and binding with HLA-DRB1*0101, HLA-DRB1*0301 (DR17), HLA-DRB1*0401 (DR4Dw4), HLA-DRB 1*0701, HLA-DRB1*1101, HLA-DRB1*1501 (DR2b), and/or HLA-DRB5*0101. Considering the epitope's affinity, ligation strength, and hydrophilicity, LRLLRRRRRRAIQEE sequence (aa 90-104) restricted by HLA-DRB1*0101, HLA-DRB1*0301 (DR17), and HLA-DRB1*0401 (DR4Dw4) was considered as the most potential MHC-II epitope in GRA5 of T. gondii. These results would be useful for studies concerning in developing T. gondii vaccine and diagnostic method.
机译：弓形虫致尖（GOTEII）的致密粒状（GRA）蛋白已被证明是T.Gondii疫苗抗原的潜在来源。然而，GRA5蛋白的数据有限。本研究分析了T.Gondii GT1，RH，ME49，VEG，MAS，RUB，FOU，P89，VAND和GAB2-2007-GAL-DOM2菌株的二十一完整GRA5序列，以识别由主要组织相容性复杂类限制的潜在表位II（MHC-II）分子（人白细胞抗原（HLA）-DP，HLA-DQ和HLA-DR）在蛋白质中。在所有T.Gondii菌株中，位于氨基酸（AA）15-29,16-30,17-31,18-32,19-33,83-97,84-98,86-100,87-101的肽预计，89-103和90-104预计将高亲和力和与HLA-DRB1 * 0101，HLA-DRB1 * 0301（DR17），HLA-DRB1 * 0401（DR4DW4），HLA-DRB 1 * 0701，HLA结合-drb1 * 1101，HLA-DRB1 * 1501（DR2B）和/或HLA-DRB5 * 0101。考虑到所关联的亲和力，连接强度和亲水性，由HLA-DRB1 * 0101，HLA-DRB1 * 0301（DR17）和HLA-DRB1 * 0401（DR4DW4）限制的LRLRRRRRAIQEE序列（AA 90-104）被认为是最多的T.Gondii Gra5中的潜在MHC-II表位。这些结果对于在开发Gondii疫苗和诊断方法方面有助于研究。

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