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首页> 外文会议>International Conference on Biological Sciences and Technology >Mechanisms of Biotherapy Effect of Shenfoweikang Herbs on Gastric Carcinoma Cells
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Mechanisms of Biotherapy Effect of Shenfoweikang Herbs on Gastric Carcinoma Cells

机译：神派康草药对胃癌细胞的生物治疗作用机制

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To explore the biotherapy effect of Shenfoweikang herbs in treatment of gastric cancer, BALB/C mice were grafted with a mouse gastric adenocarcinoma cell line MFC as the experimental model. The mice were divided into four groups. Mice in the experimental groups received different doses of Shenfoweikang herbs over a 60-day period starting at the first day after grafting. Mice received saline as controls. All the mice were sacrificed at 61 days after being grafted. Tumor size was periodically measured during the life of the mice and tumor weight was determined by an electron balance immediately after the animals killed. Serum cytokines, granzyme B and perforin were examined by the ELISA method. The anti-tumor effect was detected by the cytotoxic T-lymphocyte (CTL) assays. Our results demonstrated that Shenfoweikang herbs could inhibit the growth of gastric cancer by activating the CTLs and inducing the secretion of cytokines, perforin and granzyme B. Our study suggests that Shenfoweikang herbs inhibited the proliferation of gastric carcinoma by activating the effects of immune cells, which may lay a better basis for further study on gastric cancer biotherapy.
机译：探索Shenfoweikang草药治疗胃癌的生物治疗效果，BALB / c小鼠用小鼠胃腺癌细胞系MFC作为实验模型接枝。将小鼠分成四组。小鼠在实验组接受不同剂量的Shenfoweikang草药在60天期间接枝后开始的第一天。小鼠接受盐水作为对照。所有小鼠在61天而嫁接后处死。肿瘤大小的小鼠和肿瘤重量的寿命用电子天平后立即将动物杀死确定期间定期测量。血清细胞因子，粒酶B和穿孔通过ELISA法检测。由细胞毒性T淋巴细胞（CTL）测定法检测到的抗肿瘤作用。我们的研究结果表明，Shenfoweikang草药可以通过激活CTL和诱导细胞因子的分泌，穿孔素，颗粒酶B.我们的研究表明Shenfoweikang草药通过激活免疫细胞的作用，抑制胃癌细胞增殖抑制胃癌的生长，其可以奠定在胃癌生物治疗进一步研究提供了更好的基础。

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