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Safety Evaluation of Diethyl Citrate and Its Impact on Vascular Calcification

机译:柠檬酸二乙酯的安全评价及其对血管钙化的影响

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To investigate the inhibitory effects of diethyl citrate (Et_2Cit) on calcification, Et_2Cit was given to animals (SD rats) of the vascular calcification model. The results showed that Et_2Cit is safety and non-toxic by intraperitoneal administration. Compared with control group, Et_2Cit can reduce tail artery pressure and significantly reduce the calcium salt of vascular membrane elastic fibers on aortic Von Kossa staining. Et_2Cit has anti-vascular calcification effect and has no side effect. This result will help to provide a new research direction and theoretical basis for the prevention and treatment of vascular calcification.
机译:为了研究柠檬酸二乙酯(ET_2CIT)对钙化的抑制作用,给予血管钙化模型的动物(SD大鼠)的ET_2cit。结果表明,ET_2CIT是腹膜内给药的安全性和无毒。与对照组相比,ET_2CIT可以减少尾动压力,并显着减少主动脉膜瘤染色血管膜弹性纤维的钙盐。 ET_2CIT具有抗血管钙化效果,没有副作用。这一结果将有助于为预防和治疗血管钙化提供新的研究方向和理论依据。

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