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首页> 外文会议>Nestlé Nutrition Institute Workshop >Endocrine and Metabolic Biomarkers Predicting Early Childhood Obesity Risk
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Endocrine and Metabolic Biomarkers Predicting Early Childhood Obesity Risk

机译：预测儿童早期肥胖风险的内分泌和代谢生物标志物

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There is growing evidence of long-term effects of early dietary intervention in infancy on later obesity risk. Many studies showed reduced risk of obesity with breastfeeding in infancy, which could be related to the reduced protein intake with human milk compared to infant formula. In a randomized controlled trial (Childhood Obesity Project), we were able to show that infant formula with reduced protein content results in lower BMI both at 2 and 6 years. These effects seem to be mediated mainly by branched-chain amino acids which stimulate the insulin-like growth factor (IGF)-I axis and insulin release. In this trial, we also showed an influence of high-protein diet on larger kidney size, which seems to be partly explained by a significant effect of free IGF-1 on kidney volume. The IGF-1 axis was shown to regulate early growth, adipose tissue differentiation and early adipogenesis in animals and in humans. Leptin and adiponectin can also be regarded as important endocrine regulators of obesity. These markers were tested in observational studies. Leptin seems to be closely correlated with BMI but changes in adiponectin require further exploration. Still, there is a lack of good data or some results are contradictory to indicate the role of either leptin or adiponectin in infancy for determining later obesity risk.
机译：在初期肥胖风险上，日期饮食干预的长期效果越来越多地存在证据。许多研究表明，婴儿母乳喂养的肥胖风险降低，与婴儿配方配方相比，与人乳的蛋白质摄入量有关。在随机对照试验（儿童肥胖项目）中，我们能够表明婴儿配方含量降低的蛋白质含量在2和6年内导致较低的BMI。这些效果似乎主要由支链氨基酸介导，刺激胰岛素样生长因子（IGF）-I轴和胰岛素释放。在该试验中，我们还表现出高蛋白质饮食对较大的肾小写的影响，这似乎是通过自由IGF-1对肾脏体积的显着效果进行部分解释的。 IGF-1轴被显示为调节早期生长，脂肪组织分化和在动物和人类中的早期脂肪组织。瘦素和脂联素也可被视为肥胖的重要内分泌调节因素。这些标记在观察研究中进行了测试。瘦素似乎与BMI密切相关，但脂联素的变化需要进一步的探索。尽管如此，缺乏良好的数据或一些结果是矛盾，表明瘦素或脂肪蛋白在婴儿期用于确定后来的肥胖风险的作用。

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