The growth of population and industrialization combined with land development along river cause water pollution and environmental deterioration. Cisadane River is one of the river in Indonesia where urbanization, industrialization, and agricultural are extremely main sources of pollution. Cisadane River is an interesting case for investigating the effect of land use to water quality and comparing water quality in every river segment. The main objectives with this study were to examine if there is a correlation between land use and water quality in Cisadane River and there is a difference in water quality between the upstream section of Cisadane River compared with its downstream section. This study compared water quality with land use condition in each segment of river. Land use classification showed that river segment that has more undeveloped area has better water quality compared to river segment with developed area. in general, BOD and COD values have increased from upstream to downstream. However, BOD and COD values do not show a steady increase in each segment Water quality is closely related to the surrounding land use. Therefore, it can not be concluded that the water quality downstream is worse than in the upstream area.
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