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首页> 外文会议>IORA International Conference on Operations Research >Antihyperglicemic capacity of basil (Ocimum basilicum L.) leaves extracts coated with the marine fish scales derived nanochitosan
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Antihyperglicemic capacity of basil (Ocimum basilicum L.) leaves extracts coated with the marine fish scales derived nanochitosan

机译：罗勒（OCimum Basilicum L.）的抗静糖能力留下涂有纳米分子的海洋鱼鳞的提取物

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Basil (Ocimum basilliciim L.) is well-known as a medicinal plant and culinary herb because of its phytochemical contents. Crude extracts of basil leaves are of particular interest for health benefits, including in reducing blood glucose level. Nanochitosan is potentially applied to increase the efficacy of phytopharmaceuticals due to its low viscosity that easily absorbed by the tissues. This study was conducted to evaluate the antihyperglicemic capacity of basil leaf extracts when coated with nanochitosan. Nanochitosan was prepared from the parrot fish (Scarus sp) scales derived Chitosan by using the gelatin ionic method. Both chitosan and nanochitosan were characterized by Fourier Transform Infrared Spectroscopy (FTIR), SEM, particle sizing and heavy metals analyses. Extraction of basil leaves were performed by a maceration method using ethanol 96% and the extract was evaporated. Nanochitosan was then applied as coatings of the extracts, and the nanochitosan coated extract was separated from the solution by centrifugation. In vivo assay was applied using 24 male rats, which divided into extract treated groups and the control groups. All the animals were fasted for 12 h, but were allowed free access to water, before commencement of the experiments. Hyperglycemia condition was induced by a single intraperitoneal dose of 120 mg/kg. The rats were fasted for 12 h and blood was taken from the tail artery of the rats. The extract of basil leaves at the dose of 400, 800, 1000 mg/kgBW significantly lowered blood glucose level (P<0,05) of rat in hyperglycemic after 5 hours of extract administration. The efficacy of antihypeglicemic dose of basil leaves extracts coated with nanochitosan was found to be 400 mg/kgBW. Based on the result of the study, it is suggested that nanochitosan could increase the efficacy of phytopharmaceuticals.
机译：罗勒（OCimum Basilliciim L.）由于其植物化学含量，众所周知的药用植物和烹饪草本植物。罗勒叶的粗提取物对健康益处特别感兴趣，包括减少血糖水平。由于其易受由组织吸收的低粘度，纳米尼沙坦可能施加以增加植物药物的疗效。进行该研究以评价涂覆纳米锡时罗勒叶提取物的抗静糖能力。通过使用明胶离子法从鹦鹉鱼（疤痕SP）鳞片中制备纳米分子。壳聚糖和纳米锡的特征在于傅里叶变换红外光谱（FTIR），SEM，颗粒尺寸和重金属分析。通过使用乙醇96％的丙烷方法进行罗勒叶的提取，萃取液蒸发。然后将纳米分子作为萃取液的涂层施加，并通过离心将纳米孔涂覆的提取物与溶液分离。使用24只雄性大鼠施用体内测定，分为提取物处理的基团和对照组。所有的动物都禁食了12小时，但在实验开始之前被允许自由进入水。由120mg / kg的单个腹膜内剂量诱导高血糖病症。大鼠禁食12小时，从大鼠的尾动脉中取出血液。罗勒叶的提取物在400,800,1000mg / kgBW的剂量下显着降低了大鼠提取物给药5小时后高血糖血糖水平（P <0.05）大鼠的大鼠。发现碱叶片叶片叶片涂有纳米盐叶的疗效为400mg / kgbw。基于该研究的结果，建议纳米锡可以增加植物药物的功效。

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