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首页> 外文会议>Conference on optical tomography and spectroscopy of tissue XII >Observation of chest tumor using diffuse optical spectroscopy: Time-varying indocyanine green concentration in rabbit model
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Observation of chest tumor using diffuse optical spectroscopy: Time-varying indocyanine green concentration in rabbit model

机译：弥漫光谱观察胸腔肿瘤：兔模型时变吲哚菁绿浓度

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This experiment was conducted by using the diffuse optical spectroscopy based on near-infrared light. The near-infrared light in the water window was used to see the change of molecular concentration in the living tissue. The experiment subject was New Zealand rabbits weighing 3 ± 0.3 kg. VX2 tumor cells were injected into the inside of the chest wall of rabbits. The concentration of indocyanine green (ICG) has been observed once every three days, after the size of the pleural tumor grew up over 1cm. We used five different wavelengths (732, 758, 805, 840, and 880 nm) with known ICG spectrum. The distance between light source and detector probes was fixed by 1 cm. The probes were placed on the skin right above the tumor with an aid of laparoscope. ICG was injected into rabbits via ear vein. The diffused light was measured through the tumor with time course using a spectrometer. These measured data enabled us to observe the change of ICG concentration in real time with respect to the baseline without ICG. ICG was present longer in tumor compared to normal tissue. This phenomenon is thought to be due to the excessive angiogenesis in the tumor tissue. Since this method can be applied to other cases easily, it is thought that there is a possibility of cancer screening with less cost and simple equipment.
机译：通过使用基于近红外光的漫射光谱进行该实验。水窗中的近红外光用于看到活组织中分子浓度的变化。实验主题是重量为3±0.3千克的新西兰兔。将Vx2肿瘤细胞注入兔胸壁内侧。在胸腔肿瘤的大小超过1cm后，每三天观察一次吲哚菁绿（ICG）的浓度。我们使用了具有已知ICG谱的五个不同波长（732,758,805,840和880nm）。光源和检测器探针之间的距离固定1cm。探针伴随着腹腔镜的肿瘤右上方的皮肤。 ICG通过耳静脉注射到兔子中。使用光谱仪通过肿瘤测量漫射光。这些测量数据使我们能够在没有ICG的情况下实时观察ICG浓度的变化。与正常组织相比，ICG在肿瘤中呈现较长。这种现象被认为是由于肿瘤组织中过量的血管生成。由于这种方法可以容易地应用于其他情况，因此认为存在癌症筛查的可能性较低，设备简单。

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