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首页> 外文会议>Optical tomography and spectroscopy of tissue XII >Observation of chest tumor using diffuse optical spectroscopy: Time-varying indocyanine green concentration in rabbit model
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Observation of chest tumor using diffuse optical spectroscopy: Time-varying indocyanine green concentration in rabbit model

机译：漫射光谱法观察胸部肿瘤：兔模型中吲哚菁绿的时变浓度

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This experiment was conducted by using the diffuse optical spectroscopy based on near-infrared light. The near-infrared light in the water window was used to see the change of molecular concentration in the living tissue. The experiment subject was New Zealand rabbits weighing 3 ± 0.3 kg. VX2 tumor cells were injected into the inside of the chest wall of rabbits. The concentration of indocyanine green (ICG) has been observed once every three days, after the size of the pleural tumor grew up over 1cm. We used five different wavelengths (732, 758, 805, 840, and 880 nm) with known ICG spectrum. The distance between light source and detector probes was fixed by 1 cm. The probes were placed on the skin right above the tumor with an aid of laparoscope. ICG was injected into rabbits via ear vein. The diffused light was measured through the tumor with time course using a spectrometer. These measured data enabled us to observe the change of ICG concentration in real time with respect to the baseline without ICG. ICG was present longer in tumor compared to normal tissue. This phenomenon is thought to be due to the excessive angiogenesis in the tumor tissue. Since this method can be applied to other cases easily, it is thought that there is a possibility of cancer screening with less cost and simple equipment.
机译：该实验是使用基于近红外光的漫射光谱法进行的。水窗中的近红外光用于观察活组织中分子浓度的变化。实验对象是体重为3±0.3公斤的新西兰兔。将VX2肿瘤细胞注射到兔子的胸壁内部。在胸膜肿瘤长到1cm以上后，每三天观察一次吲哚菁绿（ICG）的浓度。我们使用了五个具有已知ICG光谱的不同波长（732、758、805、840和880 nm）。光源和探测器探头之间的距离固定为1 cm。借助腹腔镜将探针置于肿瘤上方的皮肤上。 ICG通过耳静脉注射到兔子体内。使用分光计随时间推移测量穿过肿瘤的漫射光。这些测量的数据使我们能够实时观察到ICG浓度相对于没有ICG的基线的变化。与正常组织相比，ICG在肿瘤中的存在时间更长。该现象被认为是由于肿瘤组织中过度的血管生成。由于该方法可以容易地应用于其他情况，因此认为可以以较低的成本和简单的设备进行癌症筛查。

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