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首页> 外文期刊>Physiological measurement >Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits
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Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits

机译：宽带漫射光谱法测定家兔血容量不足时血红蛋白浓度

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Serial blood draws for the assessment of trauma patients' hemoglobin (sHgb) and hematocrit (sHct) is standard practice. A device that would allow for continuous real-time, non-invasive monitoring of hemoglobin and tissue perfusion would potentially improve recognition, monitoring and resuscitation of blood loss. We developed a device utilizing diffuse optical spectroscopy (DOS) technology that simultaneously measures tissue scattering and near-infrared (NIR) absorption to obtain non-invasive measurements of oxy(Hb-O-2), deoxyhemoglobin (Hb-R) concentrations and tissue hemoglobin concentration (THC) in an animal model of hypovolemic shock induced by successive blood withdrawals. Intubated New Zealand White rabbits (N = 16) were hemorrhaged via a femoral arterial line every 20 min until a 20% blood loss (10-15 cc kg(-1)) was achieved to attain hypovolemia. A broadband DOS probe placed on the inner thigh was used to measure muscle concentrations of Hb-O-2 and Hb-R, during blood withdrawal. THC and tissue hemoglobin saturation (STO2) were calculated from DOS [Hb-O-2] and [Hb-R]. Broadband DOS-measured values were compared against traditional invasive measurements: systemic sHgb, arterial oxygen saturation (SaO2) and venous oxygen saturation (SvO2) drawn from arterial and central venous blood. DOS and traditional invasive measurements versus blood loss were closely correlated (r(2) = 0.96) showing a decline with removal of blood. STO2 and [Hb-O-2] followed similar trends with hemorrhage, while [Hb-R] remained relatively constant. These measurements may be limited to some extent by the inability to distinguish between hemoglobin and myoglobin contributions to DOS signals in tissue at this time. Broadband DOS provides a potential platform for reliable non-invasive measurements of tissue oxygenated and deoxygenated hemoglobin and may accurately reflect the degree of systemic hypovolemia and compromised tissue perfusion.
机译：标准操作是抽取连续血液以评估创伤患者的血红蛋白（sHgb）和血细胞比容（sHct）。能够连续实时，非侵入性地监测血红蛋白和组织灌注的设备将潜在地改善失血的识别，监测和复苏。我们开发了一种利用扩散光谱（DOS）技术的设备，该设备可以同时测量组织散射和近红外（NIR）吸收，从而获得对氧（Hb-O-2），脱氧血红蛋白（Hb-R）浓度和组织的无创测量连续抽血引起的低血容量性休克动物模型中的血红蛋白浓度（THC）。插管的新西兰白兔（N = 16）每20分钟通过股动脉管线出血一次，直到失血量达到20％（10-15 cc kg（-1））以达到血容量不足。在抽血过程中，将大腿内侧的宽带DOS探针用于测量Hb-O-2和Hb-R的肌肉浓度。 THC和组织血红蛋白饱和度（STO2）由DOS [Hb-O-2]和[Hb-R]计算得出。将宽带DOS测量值与传统侵入性测量值进行了比较：全身sHgb，动脉血氧饱和度（SaO2）和从动脉和中央静脉血中提取的静脉血氧饱和度（SvO2）。 DOS与传统的侵入性测量与失血量密切相关（r（2）= 0.96），显示随着血液去除而下降。 STO2和[Hb-O-2]的出血趋势相似，而[Hb-R]保持相对恒定。由于此时无法区分血红蛋白和肌红蛋白对组织中DOS信号的贡献，因此这些测量值可能会受到一定程度的限制。宽带DOS为可靠的非侵入性组织氧化和脱氧血红蛋白测量提供了一个潜在的平台，并且可以准确反映全身血容量不足和组织灌注受损的程度。

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