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首页> 外文会议>Annual Meeting of the Japanese Society for Dialysis Therapy. >Clinical Effectiveness of Intermittent infusion Hemodiafiltration Using Backfiltration of Ultrapure Dialysis Fluid Compared with Predilution On-Line Hemodiafiltration
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Clinical Effectiveness of Intermittent infusion Hemodiafiltration Using Backfiltration of Ultrapure Dialysis Fluid Compared with Predilution On-Line Hemodiafiltration

机译：使用超纯透析液的间歇输注血液过滤液的临床疗效与超纯透析液相比，术后血液血液过滤

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Background: In conventional hemodialysis (HD) treatment, excessive water removal sometimes induces a rapid drop in blood pressure. Intermittent infusion hemodiafiltration (I-HDF) has been developed to improve patients' peripheral circulation by repeated intermittent infusion during HD treatment. Summary: A prospective, multi-center, parallel group comparative trial examined the clin-icai effectiveness of I-HDF compared with predilution online HDF (pre-HDF), the most popular on-line HDF therapy in Japan. Patients were allocated to 2 groups after matching for age (± 5 years), dry weight (± 5 kg), and presence/ absence of diabetes. After informed consent was obtained, 36 patients (18 pairs) participated in the trial. The results showed no difference in clinical condition or quality of life (QOL) scores between the 2 therapy groups. The rate of reduction in systolic blood pressure initially showed no difference between the groups, but decreased slightly as the trial proceeded after changing from HD therapy. There was also no difference in the incidence rate of treatments initially, although this significantly decreased in both groups as the trial proceeded. Rates of beta_2-microglobulin removal were significantly higher in the pre-HDF group than in the I-HDF group. At the same time, the amount of albumin leakage during treatment was significantly greater in the pre-HDF group. Key Messages: The clinical condition and QOL of patients receiving I-HDF was not inferior to those receiving pre-HDF. Pre-HDF demonstrated a significantly higher removal rate of middle-and larger-molecular-weight solutes and higher albumin leakage compared with I-HDF.
机译：背景技术：在常规血液透析（HD）处理中，过度除水有时会诱导血压迅速下降。已经开发出间歇性输注血液氮化（I-HDF）以通过在高清处理期间反复间歇输注来改善患者的外周循环。摘要：前瞻性，多中心，并行组比较试验检测了I-HDF的Clin-Icai效果与术后HDF（Pre-HDF），是日本最受欢迎的在线HDF治疗。患者在匹配年龄（±5年）后分配给2组，干重（±5千克）和存在/不存在糖尿病。在获得知情同意后获得，36名患者（18对）参加了审判。结果表明，2种治疗组之间的临床状况或寿命质量（QOL）评分没有差异。收缩压的降低率最初在群体之间没有差异，但随着试验在从高清疗法改变后进行时，略微下降。最初的治疗发病率也没有差异，尽管这两个群体在试验期间的情况下显着下降。在HDF组中除去β2-微球蛋白去除率明显高于I-HDF组。同时，在HDF组中处理期间的白蛋白泄漏量明显更大。关键消息：接受I-HDF的患者的临床状况和QoL不逊于接受预级的那些。与I-HDF相比，HDF证明了中较高的中较高和较大分子量溶质的去除率和更高的白蛋白泄漏。

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