• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Tropical Renewable Energy Conference >Utilization of microalgae Spirulina platensis as a raw material for making capsule shell
【24h】

Utilization of microalgae Spirulina platensis as a raw material for making capsule shell

机译：微藻螺旋藻铂作为制造胶囊壳的原料

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Research on capsule shells has been developed to replace gelatin capsule because it made from pig skin, so it is not halal for consumption. With this problem, carrageenan is used as a substitute for gelatin, because it has properties as a gelling agent but still has a weakness that is not stable in stomach. The purpose of this study was to use microalgae Spirulina platensis because it contains polyhydroxybutyrate (PHB) which are the kind of polymer to improve performance as a drug delivery agent and prolongs the dissolution of the drugs so that the drug will be released into the intestine. The formulation of the solution that used in this research is variation of Spirulina platensis biomass (1%, 1.5%, 2%, 2.5%, 3%) (w/v). The best formulation was determined by capsule shell performance when characterization tests, such as moisture content test, pH, resistance in water, durability in acid solution test, and flexibility. This parameter follow Departemen Kesehatan RI. The best concentration of S. platensis in this research is 3% (w/v), with characterization that obtained as follows: moisture content is 15.77%, pH is 6.5, dissolve in water in 31 minutes 25 seconds, dissolve in acid environment in 35.23, and flexible when merged between cap and body. This capsule can survive in acid condition at pH 1.2 for 75 minutes and release 61.30% of drugs, the at pH 4.5 release 54.90% of drugs at 120 seconds, and the last at pH 6.8 can release 89.58% of drugs. The concentration of biomass affect to the thickness of capsule shell, disintegration time of capsule, and time for dissolution of the capsule shell. With these parameters, it is expected that the capsule form will have stiff and strong structure and not easily degraded at acid environment, so the drug will be released at intestine.
机译：已经开发出胶囊壳的研究，以取代明胶胶囊，因为它由猪皮制成，因此它不是消耗的清真机。通过这个问题，角叉菜胶用作明胶的替代品，因为它具有胶凝剂的性质，但仍然存在胃中不稳定的弱点。本研究的目的是使用微藻螺旋藻铂，因为它含有多羟基丁酸酯（PHB），其是改善性能作为药物递送剂的聚合物，延长药物的溶解，使药物释放到肠中。本研究中使用的溶液的制剂是螺旋藻铂生物质的变化（1％，1.5％，2％，2.5％，3％）（W / V）。当表征试验时，通过胶囊壳性能测定最佳配方，例如水分含量试验，pH，水性耐水性，耐酸溶液试验中的耐久性以及柔韧性。这个参数跟随Disharedemen Kesehatan Ri。本研究中最佳浓度为3％（w / v），表征如下：水分含量为15.77％，pH为6.5，在31分25秒内溶解在水中，溶解于酸环境中35.23，在帽和身体之间合并时灵活。该胶囊可以在pH 1.2的酸条件下存活75分钟，并释放出61.30％的药物，在pH 4.5释放54.90％的药物120秒，最后在pH 6.8释放89.58％的药物。生物质的浓度影响胶囊壳的厚度，胶囊的崩解时间，以及胶囊壳溶解的时间。通过这些参数，预计胶囊形式将具有僵硬和强的结构，并且在酸性环境下不易降解，因此药物将在肠道释放。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号